神经科学
谷氨酸受体
致电离效应
多发性硬化
NMDA受体
脱髓鞘病
肌萎缩侧索硬化
受体
视神经脊髓炎
脱髓鞘病
中枢神经系统
医学
生物
免疫学
疾病
内科学
作者
Amir Parsa Abhari,Masoud Etemadifar,Niloufar Yazdanpanah,Nima Rezaei
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2022-11-01
卷期号:22 (20): 2624-2640
标识
DOI:10.2174/1389557522666220504135853
摘要
N-methyl-D-aspartate receptors (NMDARs) are ionotropic glutamate receptors, highly important in regulating substantial physiologic processes in the brain and the nervous system, and disturbance in their function could contribute to different pathologies. Overstimulation and hyperactivity of NMDARs, termed glutamate toxicity, could promote cell death and apoptosis. Meanwhile, their blockade could lead to dysfunction of the brain and nervous system. A growing body of evidence has demonstrated the prominent role of NMDARs in demyelinating disorders and anti- NMDAR encephalitis. Herein, we provide an overview of NMDARs' dysfunction in the physiopathology of demyelinating disorders such as multiple sclerosis and neuromyelitis optica spectrum disorders.
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