Electrochemical Decarboxylative Coupling of N‐Substituted Glycines under Air: Access to C3‐Aminomethylated Imidazo[1,2‐a]pyridines

Abstract An electrochemical decarboxylative aminomethylation reaction of imidazo[1,2‐ a ]pyridines with various N ‐substituted glycines in acetonitrile at room temperature has been described. The reaction could be conducted under light‐free, catalyst‐free, oxidant‐free, and air conditions, affording the C3‐aminomethylated imidazo[1,2‐ a ]pyridines in good to high yields. Remarkably, N ‐aryl, N , N ‐dialkyl, and N ‐alkyl‐ N ‐aryl glycines are all well‐tolerated in this easily handled protocol, which further expands the chemical space of bioactive imidazo[1,2‐ a ]pyridine derivatives. magnified image