类有机物
生物
祖细胞
再生(生物学)
细胞生物学
功能(生物学)
干细胞
活体细胞成像
神经科学
计算生物学
细胞
遗传学
作者
Rashmiparvathi Keshara,Yung Hae Kim,Anne Grapin-Botton
标识
DOI:10.1146/annurev-cellbio-120320-035146
摘要
Organoids are miniaturized and simplified versions of an organ produced in vitro from stem or progenitor cells. They are used as a model system consisting of multiple cell types forming an architecture relevant to the organ and carrying out the function of the organ. They are a useful tool to study development, homeostasis, regeneration, and disease. The imaging of organoids has become a pivotal method to visualize and understand their self-organization, symmetry breaking, growth, differentiation, and function. In this review, we discuss imaging methods, how to analyze these images, and challenges in organoid research.
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