医学
环境卫生
铅中毒
铅(地质)
疾病
铅暴露
血铅水平
人口
疾病负担
可归因风险
相对风险
疾病负担
中国
置信区间
内科学
生物
猫
古生物学
精神科
政治学
法学
作者
Yizhong Yan,Yunhua Hu,Hong Guo,Kangqian Lin
标识
DOI:10.1016/j.scitotenv.2022.156315
摘要
Lead is a naturally occurring metal with a range of industrial applications; however, it can cause adverse health effects upon human exposure. Even if blood lead levels (BLLs) in the human body are in the acceptable range, it is independently associated with cardiovascular disease (CVD), which is the leading cause of death in China. However, the role of lead exposure in CVD outcomes has not been quantified well. A top-down approach was adopted in this study to calculate the population attribution fraction (PAF) by combining pooled BLLs in the Chinese population reported between 2001 and 2022 with the relative risk (RR) of lead-induced CVD. Subsequently, the disease burden (DB) of lead-induced CVD was estimated and expressed in disability-adjusted life years (DALYs), and the attribution analysis about various sources of lead exposure was performed. Among Chinese adolescents and adults, BLLs of 5.50 ± 2.45 μg/dL resulted in an estimated total DB (×106 DALYs) of 2.21 (2.07-2.32) for CVD, including 1.18 (1.12-1.25), 0.71 (0.69-0.74), 0.23 (0.15-0.26), and 0.02 (0.02-0.02) for stroke, and ischemic, hypertensive, and rheumatic heart diseases, respectively. Dietary lead intake was a major contributor to the DB (68.1%), and lead ingested through food was responsible for 15.1 × 105 DALYs of the CVD burden. Guangxi, Hunan, and Yunnan regions in China reported higher BLLs in adolescents and adults, and the DB of lead-induced CVD was higher in Hunan, Henan, and Sichuan. Lead is a risk factor for CVD that can cause significant DB. Further practical and cost-effective efforts to reduce lead exposure are urgently needed.
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