Association Between Visual Acuity and Residual Retinal Fluid Following Intravitreal Anti–Vascular Endothelial Growth Factor Treatment for Neovascular Age-Related Macular Degeneration

医学 黄斑变性 视力 眼科 阿柏西普 血管抑制剂 荟萃分析 随机对照试验 科克伦图书馆 贝伐单抗 视网膜 眼压 外科 内科学 化疗
作者
Nikhil S. Patil,Andrew Mihalache,Arjan S. Dhoot,Marko Popović,Rajeev H. Muni,Peter J. Kertes
出处
期刊:JAMA Ophthalmology [American Medical Association]
卷期号:140 (6): 611-611 被引量:9
标识
DOI:10.1001/jamaophthalmol.2022.1357
摘要

The association between residual subretinal fluid (SRF) and intraretinal fluid (IRF) and visual acuity following anti-vascular endothelial growth factor (VEGF) treatment is not well understood.To examine the association of residual retinal fluid, SRF, and IRF with visual acuity following anti-VEGF treatment in patients with neovascular age-related macular degeneration (nAMD).A systematic literature search was performed from January 2005 to August 2021 using Ovid MEDLINE, Embase, and the Cochrane Library.Peer-reviewed articles reporting on visual acuity stratified by the presence or absence of any residual SRF, IRF, or any retinal fluid at last study observation after intravitreal bevacizumab, ranibizumab, aflibercept, or brolucizumab in patients with nAMD were included. Studies that were noncomparative, included fewer than 10 eyes, or reported on other anti-VEGF agents were excluded.Two independent reviewers conducted data extraction and synthesis. The Cochrane risk of bias tool 2 and ROBINS-I were used to assess risk of bias and GRADE evaluation was conducted to assess certainty of evidence.Primary outcomes were BCVA at last study observation, change in BCVA from baseline, and retinal thickness at last study observation.In this systematic review and meta-analysis, 11 studies (6 randomized clinical trials [RCTs]) comprising 3092 eyes were included in our analysis. Across all included studies, the BCVA of eyes with residual SRF was better than eyes without SRF (weighted mean difference [WMD], 3.1 letter score; 95% CI, 0.05 to 6.18; P = .05; GRADE, low certainty of evidence; 6 studies; 1931 eyes) but similar in RCTs (WMD, 2.7 letter score; 95% CI, -2.40 to 7.84; P = .30; GRADE, low certainty of evidence; 3 studies; 1406 eyes). The BCVA of eyes with residual IRF was worse than that of eyes without IRF (WMD, -8.2 letter score; 95% CI, -11.79 to -4.50; P < .001; GRADE, low; 7 studies; 2114 eyes).The findings suggest that the presence of residual SRF was associated with slightly better BCVA at last study observation; however, baseline differences in BCVA existed and this conclusion was primarily driven by 1 study. The presence of residual IRF was associated with substantially worse BCVA at last study observation and less improvement of BCVA from baseline. The conclusions are limited by the inclusion of data from observational studies, heterogeneity, and a low certainty of evidence.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
NZH关闭了NZH文献求助
1秒前
Licyan完成签到,获得积分10
1秒前
科研通AI2S应助镁铝采纳,获得10
1秒前
1秒前
2秒前
Akim应助露似珍珠月似弓采纳,获得10
5秒前
醉熏的井发布了新的文献求助10
5秒前
ZYH发布了新的文献求助10
7秒前
liian7应助KYDL采纳,获得20
13秒前
小马甲应助yayan采纳,获得10
15秒前
萤火虫发布了新的文献求助10
16秒前
12345完成签到,获得积分10
17秒前
20秒前
21秒前
醉熏的井发布了新的文献求助10
22秒前
半个丸子发布了新的文献求助10
23秒前
IAMXC发布了新的文献求助10
25秒前
研究小趴菜完成签到,获得积分10
30秒前
梓泽丘墟应助channing采纳,获得10
30秒前
xy发布了新的文献求助10
30秒前
小蘑菇应助yuni采纳,获得10
31秒前
33秒前
34秒前
36秒前
more应助IAMXC采纳,获得30
38秒前
38秒前
39秒前
Inori发布了新的文献求助10
39秒前
子车茗应助zZ采纳,获得10
40秒前
雨濛濛发布了新的文献求助10
40秒前
镁铝发布了新的文献求助10
40秒前
42秒前
和谐翠丝完成签到,获得积分20
42秒前
43秒前
jiejie发布了新的文献求助30
44秒前
44秒前
醉熏的井发布了新的文献求助10
44秒前
令狐井发布了新的文献求助10
45秒前
ding应助雨濛濛采纳,获得10
46秒前
千迁jiu发布了新的文献求助10
47秒前
高分求助中
Evolution 10000
ISSN 2159-8274 EISSN 2159-8290 1000
Becoming: An Introduction to Jung's Concept of Individuation 600
Ore genesis in the Zambian Copperbelt with particular reference to the northern sector of the Chambishi basin 500
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
A new species of Velataspis (Hemiptera Coccoidea Diaspididae) from tea in Assam 500
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3161007
求助须知:如何正确求助?哪些是违规求助? 2812335
关于积分的说明 7895242
捐赠科研通 2471208
什么是DOI,文献DOI怎么找? 1315908
科研通“疑难数据库(出版商)”最低求助积分说明 631071
版权声明 602086