Air Pollution and Pediatric Respiratory Hospitalizations: Effect Modification by Particle Constituents and Oxidative Potential

微粒 置信区间 优势比 空气污染 环境化学 医学 呼吸系统 污染物 粒子数 空气污染物 臭氧 氧化磷酸化 环境卫生 环境科学 内科学 化学 体积热力学 生物化学 量子力学 物理 有机化学
作者
Jill Korsiak,Eric Lavigne,Hongyu You,Krystal J. Godri Pollitt,Ryan Kulka,Marianne Hatzopoulou,Greg J. Evans,Richard T. Burnett,Scott Weichenthal
出处
期刊:American Journal of Respiratory and Critical Care Medicine [American Thoracic Society]
卷期号:206 (11): 1370-1378 被引量:4
标识
DOI:10.1164/rccm.202205-0896oc
摘要

Rationale: Outdoor particulate and gaseous air pollutants impair respiratory health in children, and these associations may be influenced by particle composition. Objectives: To examine whether associations between short-term variations in fine particulate air pollution, oxidant gases, and respiratory hospitalizations in children are modified by particle constituents (metals and sulfur) or oxidative potential. Methods: We conducted a case-crossover study of 10,500 children (0-17 years of age) across Canada. Daily fine particle mass concentrations and oxidant gases (nitrogen dioxide and ozone) were collected from ground monitors. Monthly estimates of fine particle constituents (metals and sulfur) and oxidative potential were also measured. Conditional logistic regression models were used to estimate associations between air pollutants and respiratory hospitalizations, above and below median values for particle constituents and oxidative potential. Measurements and Main Results: Lag-1 fine particulate matter mass concentrations were not associated with respiratory hospitalizations (odds ratio and 95% confidence interval per 10 μg/m3 increase in fine particulate matter: 1.004 [0.955-1.056]) in analyses ignoring particle constituents and oxidative potential. However, when models were examined above or below median metals, sulfur, and oxidative potential, positive associations were observed above the median. For example, the odds ratio and 95% confidence interval per 10 μg/m3 increase in fine particulate matter were 1.084 (1.007-1.167) when copper was above the median and 0.970 (0.929-1.014) when copper was below the median. Similar trends were observed for oxidant gases. Conclusions: Stronger associations were observed between outdoor fine particles, oxidant gases, and respiratory hospitalizations in children when metals, sulfur, and particle oxidative potential were elevated.
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