生物
近轴中胚层
中胚层
侧板中胚层
中胚层
鹌鹑
血管生成
细胞生物学
背主动脉
体节
造血
解剖
FGF与中胚层形成
胚胎
胚胎发生
胚胎干细胞
干细胞
遗传学
内分泌学
外胚层
祖细胞
基因
作者
Luc Pardanaud,Dominique Luton,Magali Prigent,Laurent Bourcheix,Martin Catala,Françoise Dieterlen‐Lièvre
出处
期刊:Development
[The Company of Biologists]
日期:1996-05-01
卷期号:122 (5): 1363-1371
被引量:402
标识
DOI:10.1242/dev.122.5.1363
摘要
ABSTRACT We have shown previously by means of quail/chick transplantations that external and visceral organs, i.e., somatopleural and splanchnopleural derivatives, acquire their endothelial network through different mechanisms, namely immigration (termed angiogenesis) versus in situ emergence of precursors (or vasculogenesis). We have traced the distribution of QH1-positive cells in chick hosts after replacement of the last somites by quail somites (orthotopic grafts) or lateral plate mesoderm (heterotopic grafts). The results lead to the conclusion that the embryo becomes vascularized by endothelial precursors from two distinct regions, splanchnopleural mesoderm and paraxial mesoderm. The territories respectively vascularized are complementary, precursors from the paraxial mesoderm occupy the body wall and kidney, i.e., they settle along with the other paraxial mesoderm derivatives and colonize the somatopleure. The precursors from the two origins have distinct recognition and potentialities properties: endothelial precursors of paraxial origin are barred from vascularizing visceral organs and from integrating into the floor of the aorta, and are never associated with hemopoiesis; splanchnopleural mesoderm grafted in the place of somites, gives off endothelial cells to body wall and kidney but also visceral organs. It gives rise to hemopoietic precursors in addition to endothelial cells.
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