Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

XCL2型 C-C趋化因子受体6型 CCL13型 趋化因子受体 趋化因子受体 CXCR3型 CCR3 趋化因子受体CCR5 CCL21型 中央控制室4 C-C趋化因子受体7型 CCL17型 生物 趋化因子受体 CXCL16型 CCL22型 CCR1 20立方厘米 细胞生物学 分子生物学 趋化因子 免疫学 免疫系统
作者
Federica Sallusto,Danielle Lenig,Charles R. Mackay,Antonio Lanzavecchia
出处
期刊:Journal of Experimental Medicine [The Rockefeller University Press]
卷期号:187 (6): 875-883 被引量:1566
标识
DOI:10.1084/jem.187.6.875
摘要

Chemokines and their receptors are important elements for the selective attraction of various subsets of leukocytes. To better understand the selective migration of functional subsets of T cells, chemokine receptor expression was analyzed using monoclonal antibodies, RNase protection assays, and the response to distinct chemokines. Naive T cells expressed only CXC chemokine receptor (CXCR)4, whereas the majority of memory/activated T cells expressed CXCR3, and a small proportion expressed CC chemokine receptor (CCR)3 and CCR5. When polarized T cell lines were analyzed, CXCR3 was found to be expressed at high levels on T helper cell (Th)0s and Th1s and at low levels on Th2s. In contrast, CCR3 and CCR4 were found on Th2s. This was confirmed by functional responses: only Th2s responded with an increase in [Ca2+]i to the CCR3 and CCR4 agonists eotaxin and thymus and activation regulated chemokine (TARC), whereas only Th0s and Th1s responded to low concentrations of the CXCR3 agonists IFN-γ–inducible protein 10 (IP-10) and monokine induced by IFN-γ (Mig). Although CCR5 was expressed on both Th1 and Th2 lines, it was absent in several Th2 clones and its expression was markedly influenced by interleukin 2. Chemokine receptor expression and association with Th1 and Th2 phenotypes was affected by other cytokines present during polarization. Transforming growth factor β inhibited CCR3, but enhanced CCR4 and CCR7 expression, whereas interferon α inhibited CCR3 but upregulated CXCR3 and CCR1. These results demonstrate that chemokine receptors are markers of naive and polarized T cell subsets and suggest that flexible programs of chemokine receptor gene expression may control tissue-specific migration of effector T cells.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
1秒前
小强发布了新的文献求助10
2秒前
3秒前
热心如彤完成签到,获得积分10
3秒前
特梅头发布了新的文献求助20
3秒前
4秒前
6秒前
右小耳完成签到,获得积分10
7秒前
lqh0211发布了新的文献求助10
8秒前
8秒前
酷波er应助李多多采纳,获得10
8秒前
wang发布了新的文献求助10
10秒前
nickel发布了新的文献求助10
11秒前
Owen应助飘逸的山柏采纳,获得10
11秒前
贾克斯完成签到,获得积分20
12秒前
12秒前
汉堡包应助怕黑剑封采纳,获得10
13秒前
17发布了新的文献求助10
14秒前
18746005898发布了新的文献求助10
16秒前
18秒前
眼睛大鸭子完成签到,获得积分10
18秒前
LBB发布了新的文献求助10
18秒前
20秒前
21秒前
22秒前
兴奋紫完成签到,获得积分20
22秒前
不配.应助17采纳,获得20
23秒前
25秒前
无糖零脂发布了新的文献求助10
25秒前
不三不四完成签到,获得积分10
25秒前
26秒前
永远完成签到 ,获得积分10
27秒前
HY发布了新的文献求助100
27秒前
烟花应助wangxiaobin采纳,获得10
27秒前
27秒前
6000发布了新的文献求助10
28秒前
lili发布了新的文献求助10
28秒前
29秒前
lulu完成签到,获得积分10
30秒前
大模型应助hym111采纳,获得30
30秒前
高分求助中
Spray / Wall-interaction Modelling by Dimensionless Data Analysis 2000
Aspects of Babylonian celestial divination: the lunar eclipse tablets of Enūma Anu Enlil 500
Mathematics and Finite Element Discretizations of Incompressible Navier—Stokes Flows 500
India's foreign trade policy and its performance in the world economy 450
Structural Inorganic Chemistry 400
Dictionary of socialism 350
Mixed-anion Compounds 300
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3196226
求助须知:如何正确求助?哪些是违规求助? 2845058
关于积分的说明 8052686
捐赠科研通 2509593
什么是DOI,文献DOI怎么找? 1341915
科研通“疑难数据库(出版商)”最低求助积分说明 639282
邀请新用户注册赠送积分活动 608508