Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

XCL2型 C-C趋化因子受体6型 CCL13型 趋化因子受体 趋化因子受体 CXCR3型 CCR3 趋化因子受体CCR5 CCL21型 中央控制室4 C-C趋化因子受体7型 CCL17型 生物 趋化因子受体 CXCL16型 CCL22型 CCR1 20立方厘米 细胞生物学 分子生物学 趋化因子 免疫学 免疫系统
作者
Federica Sallusto,Danielle Lenig,Charles R. Mackay,Antonio Lanzavecchia
出处
期刊:Journal of Experimental Medicine [The Rockefeller University Press]
卷期号:187 (6): 875-883 被引量:1566
标识
DOI:10.1084/jem.187.6.875
摘要

Chemokines and their receptors are important elements for the selective attraction of various subsets of leukocytes. To better understand the selective migration of functional subsets of T cells, chemokine receptor expression was analyzed using monoclonal antibodies, RNase protection assays, and the response to distinct chemokines. Naive T cells expressed only CXC chemokine receptor (CXCR)4, whereas the majority of memory/activated T cells expressed CXCR3, and a small proportion expressed CC chemokine receptor (CCR)3 and CCR5. When polarized T cell lines were analyzed, CXCR3 was found to be expressed at high levels on T helper cell (Th)0s and Th1s and at low levels on Th2s. In contrast, CCR3 and CCR4 were found on Th2s. This was confirmed by functional responses: only Th2s responded with an increase in [Ca2+]i to the CCR3 and CCR4 agonists eotaxin and thymus and activation regulated chemokine (TARC), whereas only Th0s and Th1s responded to low concentrations of the CXCR3 agonists IFN-γ–inducible protein 10 (IP-10) and monokine induced by IFN-γ (Mig). Although CCR5 was expressed on both Th1 and Th2 lines, it was absent in several Th2 clones and its expression was markedly influenced by interleukin 2. Chemokine receptor expression and association with Th1 and Th2 phenotypes was affected by other cytokines present during polarization. Transforming growth factor β inhibited CCR3, but enhanced CCR4 and CCR7 expression, whereas interferon α inhibited CCR3 but upregulated CXCR3 and CCR1. These results demonstrate that chemokine receptors are markers of naive and polarized T cell subsets and suggest that flexible programs of chemokine receptor gene expression may control tissue-specific migration of effector T cells.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
明理半山完成签到,获得积分10
刚刚
RXwang发布了新的文献求助10
刚刚
刚刚
荆轲刺秦王完成签到 ,获得积分10
刚刚
研友_pLwBm8发布了新的文献求助10
1秒前
baoboalong发布了新的文献求助10
1秒前
2秒前
星辰大海应助搬砖打工人采纳,获得10
2秒前
4秒前
vv发布了新的文献求助10
4秒前
4秒前
材料摆渡人完成签到,获得积分10
5秒前
Jasper应助hukun采纳,获得10
5秒前
5秒前
xiaokezhang发布了新的文献求助10
6秒前
CipherSage应助仗炮由纪采纳,获得10
7秒前
7秒前
情怀应助hs采纳,获得10
8秒前
SciGPT应助Yolo采纳,获得10
8秒前
9秒前
seven发布了新的文献求助10
9秒前
kobeho24发布了新的文献求助30
9秒前
卡皮巴拉发布了新的文献求助10
10秒前
xx完成签到,获得积分10
10秒前
10秒前
田様应助杨琴采纳,获得10
11秒前
机灵的寻云完成签到 ,获得积分10
11秒前
文艺的筮完成签到 ,获得积分10
12秒前
研友_pLwBm8完成签到,获得积分10
12秒前
Lee发布了新的文献求助10
13秒前
狂野忆山完成签到,获得积分10
14秒前
丘比特应助怡然夏山采纳,获得10
14秒前
搬砖小丁完成签到,获得积分20
14秒前
焦糖完成签到,获得积分10
14秒前
15秒前
Yunis完成签到,获得积分10
15秒前
123发布了新的文献求助100
15秒前
Owen应助eee丶peng采纳,获得10
15秒前
15秒前
15秒前
高分求助中
Evolution 3rd edition 1500
保险藏宝图 1000
Lire en communiste 1000
Mantiden: Faszinierende Lauerjäger Faszinierende Lauerjäger 700
PraxisRatgeber: Mantiden: Faszinierende Lauerjäger 700
A new species of Coccus (Homoptera: Coccoidea) from Malawi 500
2-Acetyl-1-pyrroline: an important aroma component of cooked rice 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3184002
求助须知:如何正确求助?哪些是违规求助? 2834270
关于积分的说明 7998930
捐赠科研通 2496519
什么是DOI,文献DOI怎么找? 1332371
科研通“疑难数据库(出版商)”最低求助积分说明 636565
邀请新用户注册赠送积分活动 603843