mTORC1型
亮氨酸
生物化学
生物
氨基酸
功能(生物学)
PI3K/AKT/mTOR通路
细胞生物学
激酶
信号转导
作者
C.H.S. Aylett,Evelyn Sauer,Stefan Imseng,Daniel Boehringer,Michael N. Hall,Nenad Ban,Timm Maier
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2016-01-01
卷期号:351 (6268): 48-52
被引量:299
标识
DOI:10.1126/science.aaa3870
摘要
From sensing leucine to metabolic control The mTORC1 protein kinase complex plays central roles in regulating cell growth and metabolism and is implicated in common human diseases such as diabetes and cancer. The level of the amino acid leucine tells an organism a lot about its physiological state, including how much food is available, how much insulin is going to be needed, and whether new muscle mass can be made (see the Perspective by Buel and Blenis). Wolfson et al. identified a biochemical sensor of leucine, Sestrin2, which connects the concentration of leucine to the control of organismal metabolism and growth. When leucine bound to Sestrin2, it was released from a complex with the mTORC1 regulatory factor GATOR2, activating the mTORC1 complex. Saxton et al. describe the crystal structure of Sestrin2 and show how it specifically detects leucine. Aylett et al. determined the structure of human mTORC1 by cryoelectron microscopy and the crystal structure of a regulatory subunit, Raptor. The results reveal the structural basis for the function and intricate regulation of this important enzyme, which is also a strategic drug target. Science , this issue p. 43 , p. 48 , p. 53 ; see also p. 25
科研通智能强力驱动
Strongly Powered by AbleSci AI