克拉斯
血小板
癌症
癌症研究
信使核糖核酸
循环肿瘤细胞
生物
医学
内科学
结直肠癌
基因
转移
遗传学
作者
Myron G. Best,Nik Sol,Irsan Kooi,Jihane Tannous,Bart A. Westerman,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward P. Post,Jan Koster,Bauke Ylstra,Najim Ameziane,Josephine C. Dorsman,Egbert F. Smit,Henk M.W. Verheul,David P. Noske,Jaap C. Reijneveld,R. Jonas A. Nilsson,Bakhos A. Tannous,Pieter Wesseling,Thomas Würdinger
出处
期刊:Cancer Cell
[Elsevier]
日期:2015-11-01
卷期号:28 (5): 666-676
被引量:624
标识
DOI:10.1016/j.ccell.2015.09.018
摘要
Tumor-educated blood platelets (TEPs) are implicated as central players in the systemic and local responses to tumor growth, thereby altering their RNA profile. We determined the diagnostic potential of TEPs by mRNA sequencing of 283 platelet samples. We distinguished 228 patients with localized and metastasized tumors from 55 healthy individuals with 96% accuracy. Across six different tumor types, the location of the primary tumor was correctly identified with 71% accuracy. Also, MET or HER2-positive, and mutant KRAS, EGFR, or PIK3CA tumors were accurately distinguished using surrogate TEP mRNA profiles. Our results indicate that blood platelets provide a valuable platform for pan-cancer, multiclass cancer, and companion diagnostics, possibly enabling clinical advances in blood-based “liquid biopsies”.
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