淋巴瘤
滤泡性淋巴瘤
医学
职业暴露
病因学
慢性淋巴细胞白血病
苯乙烯
内科学
溶剂暴露
病例对照研究
病理
皮肤病科
肿瘤科
环境卫生
白血病
化学
聚合物
有机化学
共聚物
作者
A. t'Mannetje,Andrea ’t Mannetje,M. Melis,Nicholas Becker,Adele Seniori Costantini,Lenka Foretová,Lenka Foretová,Julie Mareckova,Anthony Staines,M. Maynadie,Alexandra Nieters,Paul Brennan,Paolo Boffetta,Pier Luigi Cocco
出处
期刊:Occupational and Environmental Medicine
[BMJ]
日期:2010-05-01
卷期号:67 (5): 341-347
被引量:112
标识
DOI:10.1136/oem.2009.046839
摘要
Several studies have suggested an association between occupational exposure to solvents and lymphoma risk. However, findings are inconsistent and the role of specific chemicals is not known. Objective To investigate the role of occupational exposure to organic solvents in the aetiology of B-cell non-Hodgkin's lymphoma (B-NHL) and its major subtypes, as well as Hodgkin's lymphoma and T-cell lymphoma.2348 lymphoma cases and 2462 controls participated in a case-control study in six European countries. A subset of cases were reviewed by a panel of pathologists to ensure diagnostic consistency. Exposure to solvents was assessed by industrial hygienists and occupational experts based on a detailed occupational questionnaire.Risk of follicular lymphoma significantly increased with three independent metrics of exposure to benzene, toluene and xylene (BTX) (combined p=4 x 10(-7)) and to styrene (p=1 x 10(-5)), and chronic lymphocytic leukaemia (CLL) risk increased with exposure to solvents overall (p=4 x 10(-6)), BTX (p=5 x 10(-5)), gasoline (p=8 x 10(-5)) and other solvents (p=2 x 10(-6)). Risk of B-NHL for ever exposure to solvents was not elevated (OR=1.1, 95% CI 1.0 to 1.3), and that for CLL and follicular lymphoma was 1.3 (95% CI 1.1 to 1.6) and 1.3 (95% CI 1.0 to 1.7), respectively. Exposure to benzene accounted, at least partially, for the association observed with CLL risk. Hodgkin's lymphoma and T-cell lymphoma did not show an association with solvent exposure.This analysis of a large European dataset confirms a role of occupational exposure to solvents in the aetiology of B-NHL, and particularly, CLL. It is suggested that benzene is most likely to be implicated, but we cannot exclude the possibility of a role for other solvents in relation to other lymphoma subtypes, such as follicular lymphoma. No association with risk of T-cell lymphoma and Hodgkin's lymphoma was shown.
科研通智能强力驱动
Strongly Powered by AbleSci AI