亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

The Anti-Inflammatory and Neuroprotective Effects of Ghrelin in Subarachnoid Hemorrhage-Induced Oxidative Brain Damage in Rats

神经保护 生长素 医学 氧化应激 蛛网膜下腔出血 氧化损伤 创伤性脑损伤 炎症 脑损伤 神经科学 药理学 麻醉 内科学 生物 激素 精神科
作者
Mehmet Erşahin,Hale Z. Toklu,Can Erzık,Şule Çetınel,Dilek Akakın,Ayliz Velioğlu‐Öğünç,Şermin Tetik,Zarife Nigâr Özdemir Kumral,Göksel Şener,Berrak Ç. Yeğen
出处
期刊:Journal of Neurotrauma [Mary Ann Liebert]
卷期号:27 (6): 1143-1155 被引量:93
标识
DOI:10.1089/neu.2009.1210
摘要

To elucidate the putative neuroprotective effects of ghrelin in subarachnoid hemorrhage (SAH)-induced brain injury, Wistar albino rats (n = 54) were divided into sham-operated control, saline-treated SAH, and ghrelin-treated (10 microg/kg/d IP) SAH groups. The rats were injected with blood (0.3 mL) into the cisterna magna to induce SAH, and were sacrificed 48 h after the neurological examination scores were recorded. In plasma samples, neuron-specific enolase (NSE), S-100beta protein, TNF-alpha, and IL-1beta levels were evaluated, while forebrain tissue samples were taken for the measurement of malondialdehyde (MDA), glutathione (GSH), reactive oxygen species levels, myeloperoxidase (MPO), Na(+)-K(+)-ATPase activity, and DNA fragmentation ratio. Brain tissue samples containing the basilar arteries were obtained for histological examination, while cerebrum and cerebellum were removed for the measurement of blood-brain barrier (BBB) permeability and brain water content. The neurological scores were impaired at 48 h after SAH induction, and SAH caused significant decreases in brain GSH content and Na(+)-K(+)-ATPase activity, and increases in chemiluminescence, MDA levels, and MPO activity. Compared with the control group, the protein levels of NSE, S-100beta, TNF-alpha, and IL-1beta in plasma were also increased, while ghrelin treatment prevented all SAH-induced alterations observed both biochemically and histopathologically. The results demonstrate that ghrelin alleviates SAH-induced oxidative brain damage, and exerts neuroprotection by maintaining a balance in oxidant-antioxidant status, by inhibiting proinflammatory mediators, and preventing the depletion of endogenous antioxidants evoked by SAH.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
思源应助Langsam采纳,获得50
6秒前
he完成签到 ,获得积分10
20秒前
负责念蕾完成签到 ,获得积分10
24秒前
上官凯凯完成签到 ,获得积分10
27秒前
科研通AI2S应助科研通管家采纳,获得10
31秒前
123应助科研通管家采纳,获得10
31秒前
科研通AI2S应助科研通管家采纳,获得10
32秒前
NexusExplorer应助科研通管家采纳,获得10
32秒前
FashionBoy应助科研通管家采纳,获得10
32秒前
JamesPei应助科研通管家采纳,获得10
32秒前
怀玉完成签到 ,获得积分10
35秒前
43秒前
李昕123完成签到 ,获得积分10
47秒前
55秒前
1分钟前
小小aa16完成签到,获得积分10
1分钟前
科研通AI2S应助别踩痛了雪采纳,获得10
1分钟前
Langsam发布了新的文献求助50
1分钟前
aaa发布了新的文献求助10
1分钟前
1分钟前
1分钟前
敉_发布了新的文献求助10
1分钟前
1分钟前
狐狸萌萌哒完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
1分钟前
skbkbe发布了新的文献求助10
1分钟前
岁峰柒完成签到 ,获得积分10
1分钟前
1分钟前
洋子完成签到 ,获得积分10
2分钟前
2分钟前
高贵季节发布了新的文献求助10
2分钟前
邓娅琴完成签到 ,获得积分10
2分钟前
小橙同学完成签到 ,获得积分10
2分钟前
2分钟前
123应助科研通管家采纳,获得10
2分钟前
爆米花应助科研通管家采纳,获得10
2分钟前
小马甲应助科研通管家采纳,获得10
2分钟前
高分求助中
좌파는 어떻게 좌파가 됐나:한국 급진노동운동의 형성과 궤적 2500
Sustainability in Tides Chemistry 1500
TM 5-855-1(Fundamentals of protective design for conventional weapons) 1000
Cognitive linguistics critical concepts in linguistics 800
Threaded Harmony: A Sustainable Approach to Fashion 799
Livre et militantisme : La Cité éditeur 1958-1967 500
氟盐冷却高温堆非能动余热排出性能及安全分析研究 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 催化作用 物理化学 免疫学 量子力学 细胞生物学
热门帖子
关注 科研通微信公众号,转发送积分 3052387
求助须知:如何正确求助?哪些是违规求助? 2709716
关于积分的说明 7418100
捐赠科研通 2354190
什么是DOI,文献DOI怎么找? 1245828
科研通“疑难数据库(出版商)”最低求助积分说明 605892
版权声明 595899