Enantioselective Reduction of Ketones with “Designer Cells” at High Substrate Concentrations: Highly Efficient Access to Functionalized Optically Active Alcohols

Productive cells: In a simple, highly efficient process for the synthesis of optically active alcohols, ketones are reduced by "designer cells" at high substrate concentrations and without the addition of an "external" cofactor in aqueous reaction medium. A wide range of R and S alcohols can be prepared with conversions of >90 % and enantioselectivities of >99 % ee (scheme shows results from the application on a 10-L scale). Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2006/z503394_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.