生物
福氏志贺氏菌
微生物学
沙门氏菌
大肠杆菌
细菌
志贺氏菌
赖氨酸脱羧酶
酶
霍乱弧菌
弧菌
精氨酸脱羧酶
生物化学
鸟氨酸脱羧酶
遗传学
基因
尸体
腐胺
作者
Boyu Zhao,Walid A. Houry
摘要
Enteric bacteria such as Escherichia coli have acquired a wide array of acid stress response systems to counteract the extreme acidity encountered when invading the host’s digestive or urinary tracts. These acid stress response systems are both enzyme and chaperone based. The 3 main enzyme-based acid resistance pathways are glutamate-, arginine-, and lysine-decarboxylase pathways. They are under a complex regulatory network allowing the bacteria to fine tune its response to the external environment. HdeA and HdeB are the main chaperones involved in acid stress response. The decarboxylase systems are also found in Vibrio cholera, Vibrio vulnifus, Shigella flexneri, and Salmonella typhimurium, although some differences exist in their functional mechanism and regulation.
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