肝细胞癌
癌变
长非编码RNA
生物
癌症研究
生物信息学
发病机制
疾病
基因
癌症
计算生物学
医学
遗传学
核糖核酸
内科学
免疫学
作者
Xin Yang,Xia Xie,Yufeng Xiao,Rei Xie,C. Hu,Bo Tang,Bo–Sheng Li,Shiming Yang
出处
期刊:Cancer Letters
[Elsevier BV]
日期:2015-02-23
卷期号:360 (2): 119-124
被引量:148
标识
DOI:10.1016/j.canlet.2015.02.035
摘要
Hepatocellular carcinoma (HCC) is the third cause of cancer-related death worldwide. However, the treatments for HCC are limited, and most of them are only available to the early stage. In the later stages, traditional chemotherapy has only marginal effects and may include toxicity. Thus, the identification of new predictive markers is urgently needed. New targets for non-conventional treatments will help to accelerate research on the molecular pathogenesis of HCC. A new class of transcripts, long non-coding RNAs (lncRNAs), has recently been found to be pervasively transcribed in the human genome. Aberrant expression of several lncRNAs was found to be involved in the tumorigenesis of HCC. In this review, we describe the possible molecular mechanisms that underlie lncRNA expression changes in HCC, as well as potential future applications of lncRNA research in the diagnosis and treatment of HCC.
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