Prostaglandin E2 levels in human brain tumor tissues and arachidonic acid levels in the plasma membrane of human brain tumors

花生四烯酸 前列腺素E2 前列腺素 免疫系统 生物 胶质瘤 人脑 细胞 前列腺素E 内分泌学 脑瘤 化学 内科学 生物化学 癌症研究 免疫学 病理 医学 神经科学
作者
Emine Kökoğlu,Y. Tüter,K. S. Sandikci,Zeliha Yazıcı,Emel Zengin Ulakoğlu,Hüseyin Sönmez,Emin Özyurt
出处
期刊:Cancer Letters [Elsevier BV]
卷期号:132 (1-2): 17-21 被引量:46
标识
DOI:10.1016/s0304-3835(98)00127-x
摘要

Arachidonic acid is stored in the cell membrane and released when the cell is activated by appropriate stimuli. It is the substrate for prostaglandins. Both experimental and human tumors often synthesize high levels of prostaglandins, most notably prostaglandin E2 (PGE2). Some experiments suggest that these compounds increase tumor growth through their actions on host immunocytes. In this study, 22 patients with various brain tumors and 12 control brain tissues were studied. PGE2 levels in tissue samples were measured by ELISA. Arachidonic acid levels in the plasma membrane of tissue samples were analyzed by capillary gas chromatography. The levels of PGE2 were significantly higher in gliomas (n = 10) and meningiomas (n = 7) compared with control tissues (P = 0.000 and P = 0.000, respectively). Also, PGE2 levels in meningiomas were significantly higher than in gliomas (P = 0.000). Arachidonic acid levels in the plasma membrane of gliomas (n = 9) and meningiomas (n = 6) were significantly higher than in the control tissues (P = 0.000 and P = 0.000, respectively). These results suggest that the increased production of PGE2 may suppress the immune system and play an important role in tumor growth.
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