可的松
盐皮质激素
糖皮质激素
脱氢酶
11β-羟类固醇脱氢酶1型
内分泌学
内科学
化学
基因亚型
酶
生物
生物化学
医学
基因
作者
Xue Ma,Qingquan Lian,Qiang Dong,Ren‐Shan Ge
出处
期刊:Toxicology
[Elsevier]
日期:2011-07-01
卷期号:285 (3): 83-89
被引量:77
标识
DOI:10.1016/j.tox.2011.04.007
摘要
11β-Hydroxysteroid dehydrogenase (11β-HSD) regulates glucocorticoid action by catalyzing the interconversion of active cortisol and inactive cortisone in glucocorticoid and mineralocorticoid target tissues. Two distinct isoforms, 11β-HSD1 and 11β-HSD2, have been characterized. 11β-HSD1 is widely expressed, uses NADP+/NADPH as cofactors, and contributes to the metabolic syndrome and related conditions by increasing cortisol level. 11β-HSD2 is an NAD+-dependent oxidase, converting cortisol to cortisone to lower active glucocorticoid level. The inhibition of 11β-HSD2 activity is generally detrimental to health because the buildup of local cortisol concentration can cause symptoms of apparent mineralocorticoid excess, fetal developmental defect and lower testosterone level in males. In this review, we focus on many environmental inhibitors of 11β-HSD2 including licorice components, gossypol, phthalates, organotins, alkylphenols and perfluorinated substances.
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