BCL6公司
生物
转录因子
效应器
细胞生物学
细胞毒性T细胞
谱系(遗传)
细胞分化
T细胞
免疫学
B细胞
卵泡期
遗传学
免疫系统
基因
生发中心
抗体
体外
作者
Roza Nurieva,Yeonseok Chung,Gustavo Martínez,Xuexian O. Yang,Shinya Tanaka,Tatyana D. Matskevitch,Yi-Hong Wang,Chen Dong
出处
期刊:Science
[American Association for the Advancement of Science]
日期:2009-07-24
卷期号:325 (5943): 1001-1005
被引量:1422
标识
DOI:10.1126/science.1176676
摘要
A fundamental function of CD4+ helper T (T(H)) cells is the regulation of B cell-mediated humoral immunity. Development of T follicular helper (T(FH)) cells that provide help to B cells is mediated by the cytokines interleukin-6 and interleukin-21 but is independent of TH1, TH2, and TH17 effector cell lineages. Here, we characterize the function of Bcl6, a transcription factor selectively expressed in T(FH) cells. Bcl6 expression is regulated by interleukin-6 and interleukin-21. Bcl6 overexpression induced T(FH)-related gene expression and inhibited other T(H) lineage cell differentiation in a DNA binding-dependent manner. Moreover, Bcl6 deficiency in T cells resulted in impaired T(FH) cell development and germinal center reactions, and altered production of other effector T cell subsets. Our data thus illustrate that Bcl6 is required for programming of T(FH) cell generation.
科研通智能强力驱动
Strongly Powered by AbleSci AI