Enhanced absorption and drug targeting by positively charged submicron emulsions

Drug Development ResearchVolume 50, Issue 3-4 p. 476-486 Research Overview Enhanced absorption and drug targeting by positively charged submicron emulsions Shi Cheng Yang, Shi Cheng Yang Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, IsraelSearch for more papers by this authorSimon Benita, Corresponding Author Simon Benita benita@cc.huji.ac.il Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel The David R. Bloom Center for Pharmacy at The Hebrew University of Jerusalem, Jerusalem, IsraelDepartment of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem. P.O.B. 12065, Jerusalem 91120, IsraelSearch for more papers by this author Shi Cheng Yang, Shi Cheng Yang Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, IsraelSearch for more papers by this authorSimon Benita, Corresponding Author Simon Benita benita@cc.huji.ac.il Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, Jerusalem, Israel The David R. Bloom Center for Pharmacy at The Hebrew University of Jerusalem, Jerusalem, IsraelDepartment of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem. P.O.B. 12065, Jerusalem 91120, IsraelSearch for more papers by this author First published: 16 October 2000 https://doi.org/10.1002/1098-2299(200007/08)50:3/4<476::AID-DDR31>3.0.CO;2-6Citations: 47AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Abstract This overview presents the state of the art of positively charged submicron emulsions, their physicochemical properties, biofate, and therapeutic applications, especially for intravenous, ocular, and oral administration. The positive charge of submicron emulsions results from cationic excipients such as lipids, polymers, and surfactants in formulations. It was observed that positively charged submicron emulsions are stable in the presence of physiological cations and can interact in vivo with negatively charged biological membranes, resulting in an enhanced drug uptake and site-specific targeting. Numerous authors have shown that cationic emulsions can improve the oral bioavailability of lipophilic drugs and enhance drug permeation through cornea, leading to increased drug concentration in ocular tissues as compared to negatively charged submicron emulsions. In addition, positively charged oil droplets can accumulate markedly in the lung following i.v. injection, opening new therapeutic possibilities for lung cancer chemotherapy. Drug Dev. Res. 50:476–486, 2000. © 2000 Wiley-Liss, Inc. Citing Literature Volume50, Issue3-4Special Issue: Drug Development and Biotechnology in IsraelJuly ‐ August 2000Pages 476-486 RelatedInformation