A new group of isoquinoline dimers from Hernandia voyronii

Abstract As guided by bioassay to reverse chloroquine resistance in strains of Plasmodium falciparum, three bisisoquinoline alkaloids pertaining to a novel group, the pavine-benzyltetrahydroisoquinoline dimers, were isolated from stem barks of Hernandia voyronii Jumelle. Their chemical structures were determined by conventional spectral methods assisted by the performance of the 2D NMR techniques, namely COSY LR, HMQC and HMBC.