Association of Amiodarone Use With Acute Pancreatitis in Patients With Atrial Fibrillation

Amiodarone is an antiarrhythmic frequently used in the treatment of atrial fibrillation (AF). Isolated reports have suggested that use of amiodarone may cause acute pancreatitis.1–3 This potential adverse effect of amiodarone has not been explored in large studies. We assessed whether use of amiodarone or other antiarrhythmics indicated for AF management is associated with developing acute pancreatitis in a large US population.