Effect of vitamin D on musculoskeletal pain and headache: A randomized, double-blind, placebo-controlled trial among adult ethnic minorities in Norway

安慰剂 医学 维生素D与神经学 可视模拟标度 物理疗法 人口 随机对照试验 维生素 内科学 环境卫生 病理 替代医学
作者
Kirsten V. Knutsen,Ahmed A. Madar,Mette Brekke,Helmut E. Meyer,Bård Natvig,Ibrahimu Mdala,Per Lagerlv
出处
期刊:Pain [Lippincott Williams & Wilkins]
卷期号:155 (12): 2591-2598 被引量:48
标识
DOI:10.1016/j.pain.2014.09.024
摘要

Summary Vitamin D supplementation for 16 weeks did not reduce musculoskeletal pain or headache in this randomized, double-blind, placebo-controlled study among ethnic minorities living in Norway. Immigrants from South Asia, the Middle East, and Africa living in Northern Europe frequently have low vitamin D levels and more pain compared to the native Western population. The aim of this study was to examine whether daily vitamin D3 (25 μg/d or 10 μg/d) supplementation for 16 weeks would improve musculoskeletal pain or headache compared to placebo. This randomized, double-blind, placebo-controlled, parallel-group trial recruited 251 participants aged 18 to 50 years, and 215 (86%) attended the follow-up visit. The pain measures were occurrence, anatomical localization, and degree of musculoskeletal pain, as measured by visual analogue scale (VAS) score during the past 2 weeks. Headache was measured with VAS and the Headache Impact Test (HIT-6) questionnaire. At baseline, females reported more pain sites (4.7) than males (3.4), and only 7% reported no pain in the past 2 weeks. During the past 4 weeks, 63% reported headache with a high mean HIT-6 score of 60 (SD 7). At follow-up, vitamin D level, measured as serum 25(OH)D3, increased from 27 nmol/L to 52 nmol/L and from 27 nmol/L to 43 nmol/L in the 25-μg and 10-μg supplementation groups, respectively, whereas serum 25(OH)D3 did not change in the placebo group. Pain scores and headache scores were improved at follow-up compared with baseline. The use of vitamin D supplements, however, showed no significant effect on the occurrence, anatomical localization, and degree of pain or headache compared to placebo.
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