Effects of Thyroid Hormone on Cardiac β-Adrenergic Responsiveness in Conscious Baboons

内科学 内分泌学 甲状腺 激素 医学 刺激 多巴酚丁胺 心率 肾上腺素能的 受体 血流动力学 血压
作者
Brian D. Hoit,Saeb F. Khoury,Yanfu Shao,Marjorie Gabel,Stephen B. Liggett,Richard A. Walsh
出处
期刊:Circulation [Lippincott Williams & Wilkins]
卷期号:96 (2): 592-598 被引量:99
标识
DOI:10.1161/01.cir.96.2.592
摘要

Many of the cardiovascular manifestations of thyroid hormone excess resemble those produced by sympathoadrenal stimulation. The objective of this study was to determine the effects of thyroid hormone excess on myocardial beta-adrenergic expression and responsiveness to infused agonists in the primate heart.The responses of left ventricular isovolumic contraction (dP/dt(max)) and relaxation (tau) during graded dobutamine infusion were studied both before and after 4 weeks of thyroid hormone administration in 8 chronically instrumented baboons. At matched (atrially paced) heart rates, thyroid hormone significantly increased resting dP/dt(max) (3073+/-1034 versus 2318+/-829 mm Hg/s, P<.05) and decreased tau (24.0+/-5.5 versus 28.2+/-5.4 ms, P<.05). The change from baseline for dP/dt(max) and tau in response to beta1-adrenergic stimulation was significant at each dobutamine dose (2.5 to 10 microg x kg(-1) x min(-1)), but when expressed as a percent change, it was similar before versus after thyroid hormone. Similar changes were found when beta2-adrenergic stimulation was produced by terbutaline infusion in three additional baboons. beta-Adrenergic receptor (betaAR) expression was higher in five thyroxine-treated than in five control baboons (37.4+/-1.2 versus 15.7+/-3.2 fmol/mg, P<.001), and this was due to a greater increase in the beta2AR (5.9+/-1.5 to 20.6+/-1.2 fmol/mg, P<.001) than the beta1AR (9.7+/-1.7 to 16.8+/-0.1 fmol/mg, P<.01) subtype.In the primate heart, thyroid hormone produces positive inotropic and lusitropic effects in the resting state and upregulates both beta1AR and beta2AR, with the beta2AR increase predominating. At equivalent rates, however, thyroid hormone excess does not appear to enhance the sensitivity of left ventricular contractility and relaxation to either beta1- or beta2-adrenergic stimulation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Yuantian发布了新的文献求助10
1秒前
学吗你完成签到 ,获得积分10
1秒前
御青白少发布了新的文献求助10
2秒前
无尽夏完成签到,获得积分10
2秒前
Rylee发布了新的文献求助10
4秒前
4秒前
无私的念文完成签到 ,获得积分10
5秒前
充电宝应助Yuantian采纳,获得10
6秒前
水水完成签到,获得积分10
7秒前
sskr发布了新的文献求助10
7秒前
15327432191完成签到 ,获得积分10
8秒前
酷波er应助果汁采纳,获得10
8秒前
善学以致用应助程公子采纳,获得10
8秒前
海阔天空发布了新的文献求助10
8秒前
ChemistryZyh完成签到,获得积分10
9秒前
wensir完成签到,获得积分10
11秒前
斯文败类应助Rylee采纳,获得10
12秒前
养不熟的野猫完成签到,获得积分10
12秒前
sskr完成签到,获得积分10
12秒前
高文强完成签到,获得积分10
13秒前
14秒前
我是老大应助liu采纳,获得10
14秒前
领导范儿应助小熊软糖采纳,获得10
14秒前
华仔应助kevin采纳,获得10
15秒前
16秒前
17秒前
晴朗葡萄发布了新的文献求助30
17秒前
bkagyin应助冷艳的冬萱采纳,获得10
17秒前
18秒前
文献啊文献完成签到,获得积分10
19秒前
御青白少完成签到,获得积分10
20秒前
晨晨完成签到 ,获得积分10
20秒前
Christ发布了新的文献求助20
20秒前
大方的若山完成签到,获得积分10
20秒前
董啊发布了新的文献求助10
20秒前
Wayne发布了新的文献求助10
21秒前
slby完成签到 ,获得积分10
21秒前
x971017完成签到,获得积分10
21秒前
Aqua发布了新的文献求助10
21秒前
to_ooooo完成签到,获得积分20
21秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038569
求助须知:如何正确求助?哪些是违规求助? 3576279
关于积分的说明 11374944
捐赠科研通 3305979
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815048