Role of Sarco/Endoplasmic Reticulum Ca2+-ATPase in Thermogenesis

Enzymes are able to handle the energy derived from the hydrolysis of phosphate compounds in such a way as to determine the parcel that is used for work and the fraction that is converted into heat. The sarco/endoplasmic reticulum Ca(2+)-ATPases (SERCA) is a family of membrane-bound ATPases that are able to transport Ca(2+) ion across the membrane using the chemical energy derived from ATP hydrolysis. The heat released during ATP hydrolysis by SERCA may vary from 10 up to 30 kcal/mol depending on the SERCA isoform used and on whether or not a Ca(2+) gradient is formed across the membrane. Drugs such as heparin, dimethyl sulfoxide and the platelet-activating factor (PAF) are able to modify the fraction of the chemical energy released during ATP hydrolysis that is used for Ca(2+) transport and the fraction that is dissipated in the surrounding medium as heat. The thyroid hormone 3,5,3'-triiodo L: -thyronine (T(3)) regulates the expression and function of the thermogenic SERCA isoforms. Modulation of heat production by SERCA might be one of the mechanisms involved in the increased thermogenesis found in hyperthyroidism.