吲哚胺2,3-双加氧酶
细胞生物学
免疫耐受
细胞内
免疫系统
生物
表型
转化生长因子
信号转导
诱导剂
炎症
周边公差
干扰素
免疫学
遗传学
基因
色氨酸
氨基酸
作者
Maria Teresa Pallotta,Ciriana Orabona,Claudia Volpi,Carmine Vacca,Maria Laura Belladonna,Roberta Bianchi,Giuseppe Servillo,Cinzia Brunacci,Mario Calvitti,Silvio Bicciato,Emilia Maria Cristina Mazza,Louis Boon,Fabio Grassi,Maria C. Fioretti,Francesca Fallarino,Paolo Puccetti,Maria Teresa Pallotta
摘要
Regulation of tryptophan metabolism by indoleamine 2,3-dioxygenase (IDO) in dendritic cells (DCs) is a highly versatile modulator of immunity. In inflammation, interferon-γ is the main inducer of IDO for the prevention of hyperinflammatory responses, yet IDO is also responsible for self-tolerance effects in the longer term. Here we show that treatment of mouse plasmacytoid DCs (pDCs) with transforming growth factor-β (TGF-β) conferred regulatory effects on IDO that were mechanistically separable from its enzymic activity. We found that IDO was involved in intracellular signaling events responsible for the self-amplification and maintenance of a stably regulatory phenotype in pDCs. Thus, IDO has a tonic, nonenzymic function that contributes to TGF-β-driven tolerance in noninflammatory contexts.
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