The human leucine zipper-containing guanine-nucleotide exchange protein elongation factor-1δ

Copy-DNA clones containing the complete coding region of the human elongation factor-1δ (EF-1δ) mRNA have been isolated and characterized. We present the deduced amino acid sequence and observe in it a leucine zipper motif seen recently in EF-1δ from Artemia and Xenopus laevis. The human EF-1δ sequence shows a strong conservation in its C-terminal domain. The homology between the N-terminal domains of EF-1δ proteins is low and almost exclusively limited to the leucine zipper motif.