腺苷脱氨酶
班级(哲学)
化学
立体化学
组合化学
腺苷
计算机科学
计算生物学
生物
生物化学
人工智能
作者
Sarah C. Zimmermann,Joshua M. Sadler,Peter I. O’Daniel,Nathaniel T. Kim,Katherine L. Seley‐Radtke
标识
DOI:10.1080/15257770.2013.771187
摘要
A series of flexible carbocyclic pyrimidine nucleosides has been designed and synthesized. In contrast to previously reported “fleximers” from our laboratory, these analogues have the connectivity of the heterocyclic base system “reversed”, where the pyrimidine ring is attached to the sugar moiety, rather than the five membered imidazole ring. As was previously seen with the ribose fleximers, their inherent flexibility should allow them to adjust to enzyme binding site mutations, as well as increase the affinity for atypical enzymes. Preliminary biological screening has revealed surprising inhibition of adenosine deaminase, despite their lack of resemblance to adenosine.
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