表型筛选
药物发现
布氏锥虫
有机体
计算生物学
表型
模式生物
生物
原生动物寄生虫
药物开发
药品
克鲁兹锥虫
遗传学
生物信息学
基因
药理学
计算机科学
寄生虫寄主
万维网
作者
Melissa Sykes,Vicky M. Avery
摘要
Determining the activity of a compound and the potential impact on a diseased state is frequently undertaken using phenotypic or target-based approaches. Phenotypic screens have the advantage of the whole organism being exposed to the compound and thus all the targets and biological pathways associated with it. Cell penetration and access to targets in their “natural” environment are taken into account. Unless utilizing a genetically modified organism with an additional target associated indicator, elucidation of specific target(s) of active compounds is necessary. Target discovery is desirable to allow development of chemical entities based upon knowledge of the target structure. Phenotypic drug discovery has successfully identified new molecular entities for neglected protozoan disease research. In this perspective, the phenotypic approaches used to identify chemical entities for drug discovery and for use as tools against the parasites Plasmodium falciparum, Trypanosoma brucei brucei, and Trypanosoma cruzi will be outlined.
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