亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Feasibility of Gene Therapy for Tooth Regeneration by Stimulation of a Third Dentition

再生(生物学) 牙列 刺激 牙科 医学 口腔正畸科 生物 细胞生物学 内科学
作者
Katsu Takahashi,Honoka Kiso,Kazuyuki Saito,Yumiko Togo,Hiroko Tsukamoto,Boyen Huang,Kazuhisa Bessho
出处
期刊:InTech eBooks [InTech]
被引量:16
标识
DOI:10.5772/52529
摘要

[Extract] The tooth is a complex biological organ that consists of multiple tissues, including enamel, dentin, cementum, and pulp. Missing teeth is a common and frequently occurring problem in aging populations. To treat these defects, the current approach involves fixed or removable prostheses, autotransplantation, and dental implants. The exploration of new strategies for tooth replacement has become a hot topic. Using the foundations of experimental embryology, developmental and molecular biology, and the principles of biomimetics, tooth regeneration is becoming a realistic possibility. Several different methods have been proposed to achieve biological tooth replacement[1-8]. These include scaffold-based tooth regeneration, cell pellet engineering, chimeric tooth engineering, stimulation of the formation of a third dentition, and gene-manipulated tooth regeneration. The idea that a third dentition might be locally induced to replace missing teeth is an attractive concept[5,8,9]. This approach is generally presented in terms of adding molecules to induce de novo tooth initiation in the mouth. It might be combined with gene-manipulated tooth regeneration; that is, endogenous dental cells in situ can be activated or repressed by a gene-delivery technique to produce a tooth. Tooth development is the result of reciprocal and reiterative signaling between oral ectoderm-derived dental epithelium and cranial neural crest cell-derived dental mesenchyme under genetic control [10-12]. More than 200 genes are known to be expressed during tooth development (http://bite-it.helsinki.fi/). A number of mouse mutants are now starting to provide some insights into the mechanisms of supernumerary tooth formation. Multiple supernumerary teeth may have genetic components in their etiology and partially represent the third dentition in humans. Such candidate molecules or genes might be those that are involved in embryonic tooth induction, in successional tooth formation, or in the control of the number of teeth. This means that it may be possible to induce de novo tooth formation by the in situ repression or activation of a single candidate gene. In this review, we present an overview of the collective knowledge of tooth regeneration, especially regarding the control of the number of teeth for gene therapy by the stimulation of a third dentition.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
15秒前
小叶子完成签到 ,获得积分10
15秒前
Liufgui应助徐悦月采纳,获得10
17秒前
21秒前
Dave完成签到,获得积分10
36秒前
FashionBoy应助Dave采纳,获得10
39秒前
40秒前
41秒前
44秒前
顾矜应助Emon采纳,获得10
58秒前
1分钟前
1分钟前
芝麻完成签到,获得积分10
1分钟前
1分钟前
Dave发布了新的文献求助10
1分钟前
大模型应助芝麻采纳,获得10
1分钟前
2分钟前
jjjjj发布了新的文献求助10
2分钟前
Liufgui应助花凉采纳,获得20
2分钟前
biubiubiu发布了新的文献求助10
2分钟前
万能图书馆应助章鱼采纳,获得10
2分钟前
jjjjj完成签到,获得积分20
2分钟前
2分钟前
章鱼发布了新的文献求助10
2分钟前
牛八先生完成签到,获得积分10
2分钟前
2分钟前
孙燕应助jjjjj采纳,获得30
2分钟前
Liufgui应助花凉采纳,获得20
2分钟前
Ava关闭了Ava文献求助
2分钟前
科研通AI2S应助liudy采纳,获得10
2分钟前
科研通AI2S应助sljzhangbiao11采纳,获得10
2分钟前
2分钟前
徐悦月发布了新的文献求助10
3分钟前
三笠发布了新的文献求助10
3分钟前
小刘完成签到,获得积分10
3分钟前
3分钟前
三笠完成签到,获得积分10
3分钟前
传奇3应助Liiiiiiiiii采纳,获得10
3分钟前
gt完成签到 ,获得积分10
3分钟前
3分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990045
求助须知:如何正确求助?哪些是违规求助? 3532108
关于积分的说明 11256334
捐赠科研通 3270943
什么是DOI,文献DOI怎么找? 1805146
邀请新用户注册赠送积分活动 882270
科研通“疑难数据库(出版商)”最低求助积分说明 809228