清晨好,您是今天最早来到科研通的研友!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您科研之路漫漫前行!

Feasibility of Gene Therapy for Tooth Regeneration by Stimulation of a Third Dentition

再生(生物学) 牙列 刺激 牙科 医学 口腔正畸科 生物 细胞生物学 内科学
作者
Katsu Takahashi,Honoka Kiso,Kazuyuki Saito,Yumiko Togo,Hiroko Tsukamoto,Boyen Huang,Kazuhisa Bessho
出处
期刊:InTech eBooks [InTech]
被引量:16
标识
DOI:10.5772/52529
摘要

[Extract] The tooth is a complex biological organ that consists of multiple tissues, including enamel, dentin, cementum, and pulp. Missing teeth is a common and frequently occurring problem in aging populations. To treat these defects, the current approach involves fixed or removable prostheses, autotransplantation, and dental implants. The exploration of new strategies for tooth replacement has become a hot topic. Using the foundations of experimental embryology, developmental and molecular biology, and the principles of biomimetics, tooth regeneration is becoming a realistic possibility. Several different methods have been proposed to achieve biological tooth replacement[1-8]. These include scaffold-based tooth regeneration, cell pellet engineering, chimeric tooth engineering, stimulation of the formation of a third dentition, and gene-manipulated tooth regeneration. The idea that a third dentition might be locally induced to replace missing teeth is an attractive concept[5,8,9]. This approach is generally presented in terms of adding molecules to induce de novo tooth initiation in the mouth. It might be combined with gene-manipulated tooth regeneration; that is, endogenous dental cells in situ can be activated or repressed by a gene-delivery technique to produce a tooth. Tooth development is the result of reciprocal and reiterative signaling between oral ectoderm-derived dental epithelium and cranial neural crest cell-derived dental mesenchyme under genetic control [10-12]. More than 200 genes are known to be expressed during tooth development (http://bite-it.helsinki.fi/). A number of mouse mutants are now starting to provide some insights into the mechanisms of supernumerary tooth formation. Multiple supernumerary teeth may have genetic components in their etiology and partially represent the third dentition in humans. Such candidate molecules or genes might be those that are involved in embryonic tooth induction, in successional tooth formation, or in the control of the number of teeth. This means that it may be possible to induce de novo tooth formation by the in situ repression or activation of a single candidate gene. In this review, we present an overview of the collective knowledge of tooth regeneration, especially regarding the control of the number of teeth for gene therapy by the stimulation of a third dentition.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
gengsumin完成签到,获得积分10
10秒前
xiaofeixia完成签到 ,获得积分10
15秒前
笨笨梦松完成签到,获得积分10
26秒前
东方天奇完成签到 ,获得积分10
34秒前
红茸茸羊完成签到 ,获得积分10
43秒前
hadfunsix完成签到 ,获得积分10
43秒前
郁金香完成签到,获得积分10
58秒前
简单完成签到,获得积分10
1分钟前
lifenghou完成签到 ,获得积分10
1分钟前
Herbs完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
1分钟前
小羊完成签到 ,获得积分10
1分钟前
辣辣辣辣辣辣完成签到 ,获得积分10
1分钟前
2分钟前
辣小扬完成签到 ,获得积分10
2分钟前
2分钟前
superspace完成签到 ,获得积分10
2分钟前
yshj完成签到 ,获得积分10
2分钟前
2分钟前
zxh656691发布了新的文献求助10
2分钟前
小young完成签到 ,获得积分10
2分钟前
rockyshi完成签到 ,获得积分10
2分钟前
刘辰完成签到 ,获得积分10
2分钟前
yellowonion完成签到 ,获得积分10
2分钟前
冷傲的火龙果完成签到,获得积分10
2分钟前
2分钟前
通科研完成签到 ,获得积分10
2分钟前
lingling完成签到 ,获得积分10
2分钟前
2分钟前
3分钟前
Yes0419完成签到,获得积分10
3分钟前
周周完成签到 ,获得积分10
3分钟前
美满的大象完成签到 ,获得积分10
3分钟前
不信人间有白头完成签到 ,获得积分10
3分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
3分钟前
q792309106发布了新的文献求助10
3分钟前
harden9159完成签到,获得积分10
3分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
Problems of point-blast theory 400
Indomethacinのヒトにおける経皮吸収 400
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 370
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3996002
求助须知:如何正确求助?哪些是违规求助? 3535669
关于积分的说明 11267397
捐赠科研通 3275275
什么是DOI,文献DOI怎么找? 1806560
邀请新用户注册赠送积分活动 883378
科研通“疑难数据库(出版商)”最低求助积分说明 809785