Trends in the Incidence, Prevalence, and Survival Outcomes in Patients With Neuroendocrine Tumors in the United States

医学 流行病学 人口 入射(几何) 队列 内科学 相对存活率 队列研究 人口学 癌症登记处 回顾性队列研究 监测、流行病学和最终结果 儿科 环境卫生 光学 物理 社会学
作者
Arvind Dasari,Chan Shen,Daniel M. Halperin,Bo Zhao,Shouhao Zhou,Ying Xu,Ya‐Chen Tina Shih,James C. Yao
出处
期刊:JAMA Oncology [American Medical Association]
卷期号:3 (10): 1335-1335 被引量:2958
标识
DOI:10.1001/jamaoncol.2017.0589
摘要

The incidence and prevalence of neuroendocrine tumors (NETs) are thought to be rising, but updated epidemiologic data are lacking.To explore the evolving epidemiology and investigate the effect of therapeutic advances on survival of patients with NETs.A retrospective, population-based study using nationally representative data from the Surveillance, Epidemiology, and End Results (SEER) program was conducted to evaluate 64 971 patients with NETs from 1973 to 2012. Associated population data were used to determine annual age-adjusted incidence, limited-duration prevalence, and 5-year overall survival (OS) rates. Trends in survival from 2000 to 2012 were evaluated for the entire cohort as well as specific subgroups, including distant-stage gastrointestinal NETs and pancreatic NETs. Analyses were conducted between December 2015, and February 2017.Neuroendocrine tumor incidence, prevalence, and OS rates.Of the 64 971 cases of NETs, 34 233 (52.7%) were women. The age-adjusted incidence rate increased 6.4-fold from 1973 (1.09 per 100 000) to 2012 (6.98 per 100 000). This increase occurred across all sites, stages, and grades. In the SEER 18 registry grouping (2000-2012), the highest incidence rates were 1.49 per 100 000 in the lung, 3.56 per 100 000 in gastroenteropancreatic sites, and 0.84 per 100 000 in NETs with an unknown primary site. The estimated 20-year limited-duration prevalence of NETs in the United States on January 1, 2014, was 171 321. On multivariable analyses, the median 5-year OS rate varied significantly by stage, grade, age at diagnosis, primary site, and time period of diagnosis. The OS rate for all NETs improved from the 2000-2004 period to the 2009-2012 period (hazard ratio [HR], 0.79; 95% CI, 0.73-0.85). Even larger increases in OS between these periods were noted in distant-stage gastrointestinal NETs (HR, 0.71; 95% CI, 0.62-0.81) and distant-stage pancreatic NETs (HR, 0.56; 95% CI, 0.44-0.70).The incidence and prevalence of NETs are steadily rising, possibly owing to detection of early-stage disease and stage migration. Survival for all NETs has improved over time, especially for distant-stage gastrointestinal NETs and pancreatic NETs in particular, reflecting improvement in therapies. These data will help to prioritize future research directions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
徐哈哈发布了新的文献求助10
刚刚
2秒前
3秒前
4秒前
研友_VZG7GZ应助欣喜沛芹采纳,获得10
5秒前
感动黄豆完成签到,获得积分20
6秒前
7秒前
7秒前
9秒前
11秒前
Owen应助Kikua采纳,获得10
11秒前
juliar完成签到 ,获得积分10
11秒前
12秒前
Bressanone发布了新的文献求助10
12秒前
13秒前
彭于晏应助忐忑的阑香采纳,获得10
13秒前
赘婿应助xiaojian_291采纳,获得10
13秒前
14秒前
郭小宝发布了新的文献求助20
14秒前
糊涂的语兰完成签到,获得积分10
15秒前
浮生若梦完成签到 ,获得积分10
16秒前
CA发布了新的文献求助10
16秒前
忘记时间发布了新的文献求助30
16秒前
王羊补牢完成签到,获得积分10
18秒前
19秒前
潇湘雪月发布了新的文献求助10
24秒前
栗园应助仙都丽娜采纳,获得10
25秒前
严珍珍完成签到 ,获得积分10
25秒前
思源应助郭小宝采纳,获得10
25秒前
无理完成签到 ,获得积分10
26秒前
28秒前
28秒前
无端完成签到 ,获得积分20
28秒前
感动黄豆发布了新的文献求助10
29秒前
量子星尘发布了新的文献求助10
29秒前
30秒前
zwy109发布了新的文献求助10
31秒前
33秒前
立夏完成签到,获得积分10
34秒前
34秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989242
求助须知:如何正确求助?哪些是违规求助? 3531393
关于积分的说明 11253753
捐赠科研通 3270010
什么是DOI,文献DOI怎么找? 1804868
邀请新用户注册赠送积分活动 882084
科研通“疑难数据库(出版商)”最低求助积分说明 809136