Trends in the Incidence, Prevalence, and Survival Outcomes in Patients With Neuroendocrine Tumors in the United States

医学 流行病学 人口 入射(几何) 队列 内科学 相对存活率 队列研究 人口学 癌症登记处 回顾性队列研究 监测、流行病学和最终结果 儿科 环境卫生 光学 物理 社会学
作者
Arvind Dasari,Chan Shen,Daniel M. Halperin,Bo Zhao,Shouhao Zhou,Ying Xu,Ya‐Chen Tina Shih,James C. Yao
出处
期刊:JAMA Oncology [American Medical Association]
卷期号:3 (10): 1335-1335 被引量:2958
标识
DOI:10.1001/jamaoncol.2017.0589
摘要

The incidence and prevalence of neuroendocrine tumors (NETs) are thought to be rising, but updated epidemiologic data are lacking.To explore the evolving epidemiology and investigate the effect of therapeutic advances on survival of patients with NETs.A retrospective, population-based study using nationally representative data from the Surveillance, Epidemiology, and End Results (SEER) program was conducted to evaluate 64 971 patients with NETs from 1973 to 2012. Associated population data were used to determine annual age-adjusted incidence, limited-duration prevalence, and 5-year overall survival (OS) rates. Trends in survival from 2000 to 2012 were evaluated for the entire cohort as well as specific subgroups, including distant-stage gastrointestinal NETs and pancreatic NETs. Analyses were conducted between December 2015, and February 2017.Neuroendocrine tumor incidence, prevalence, and OS rates.Of the 64 971 cases of NETs, 34 233 (52.7%) were women. The age-adjusted incidence rate increased 6.4-fold from 1973 (1.09 per 100 000) to 2012 (6.98 per 100 000). This increase occurred across all sites, stages, and grades. In the SEER 18 registry grouping (2000-2012), the highest incidence rates were 1.49 per 100 000 in the lung, 3.56 per 100 000 in gastroenteropancreatic sites, and 0.84 per 100 000 in NETs with an unknown primary site. The estimated 20-year limited-duration prevalence of NETs in the United States on January 1, 2014, was 171 321. On multivariable analyses, the median 5-year OS rate varied significantly by stage, grade, age at diagnosis, primary site, and time period of diagnosis. The OS rate for all NETs improved from the 2000-2004 period to the 2009-2012 period (hazard ratio [HR], 0.79; 95% CI, 0.73-0.85). Even larger increases in OS between these periods were noted in distant-stage gastrointestinal NETs (HR, 0.71; 95% CI, 0.62-0.81) and distant-stage pancreatic NETs (HR, 0.56; 95% CI, 0.44-0.70).The incidence and prevalence of NETs are steadily rising, possibly owing to detection of early-stage disease and stage migration. Survival for all NETs has improved over time, especially for distant-stage gastrointestinal NETs and pancreatic NETs in particular, reflecting improvement in therapies. These data will help to prioritize future research directions.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
AKYDXS完成签到,获得积分10
2秒前
昏睡的蟠桃应助Llllll采纳,获得200
2秒前
科研通AI2S应助hao采纳,获得10
2秒前
3秒前
3秒前
香蕉觅云应助阿湫采纳,获得10
4秒前
星辰大海应助星辰采纳,获得10
4秒前
阿卡宁完成签到,获得积分10
4秒前
lzw完成签到 ,获得积分10
4秒前
沉静烧仙草完成签到,获得积分20
5秒前
烟花应助嘉嘉琦采纳,获得10
5秒前
隐形曼青应助科研通管家采纳,获得10
5秒前
Hello应助科研通管家采纳,获得10
6秒前
Ava应助科研通管家采纳,获得10
6秒前
上官若男应助科研通管家采纳,获得10
6秒前
6秒前
赘婿应助科研通管家采纳,获得10
6秒前
烟花应助科研通管家采纳,获得10
6秒前
FashionBoy应助科研通管家采纳,获得10
6秒前
英俊的铭应助科研通管家采纳,获得10
6秒前
在水一方应助科研通管家采纳,获得10
6秒前
accepted应助科研通管家采纳,获得10
6秒前
脑洞疼应助科研通管家采纳,获得10
6秒前
6秒前
cdh1994应助kcmat采纳,获得10
6秒前
我是老大应助科研通管家采纳,获得10
6秒前
乐乐应助科研通管家采纳,获得10
6秒前
FashionBoy应助科研通管家采纳,获得10
6秒前
6秒前
上官若男应助科研通管家采纳,获得10
6秒前
6秒前
6秒前
6秒前
我是老大应助科研通管家采纳,获得30
6秒前
脑洞疼应助科研通管家采纳,获得20
7秒前
科目三应助科研通管家采纳,获得30
7秒前
7秒前
完美世界应助科研通管家采纳,获得10
7秒前
7秒前
7秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038524
求助须知:如何正确求助?哪些是违规求助? 3576221
关于积分的说明 11374737
捐赠科研通 3305912
什么是DOI,文献DOI怎么找? 1819354
邀请新用户注册赠送积分活动 892688
科研通“疑难数据库(出版商)”最低求助积分说明 815048