敏化
医学
神经科学
神经可塑性
神经病理性疼痛
感觉
抑制性突触后电位
中枢敏化
外围设备
免疫学
麻醉
内科学
伤害
心理学
精神科
受体
作者
Hazem Adel Ashmawi,George Miguel Góes Freire
出处
期刊:Revista DOR
[Publicidad Permanyer, SLU]
日期:2016-01-01
卷期号:17
被引量:13
标识
DOI:10.5935/1806-0013.20160044
摘要
BACKGROUND AND OBJECTIVES: Central sensitization is an important phenomenon for pain chronicity and is present in neuropathic pain. This study aimed at addressing some pathophysiological aspects of this phenomenon. CONTENTS: Some extra and intracellular aspects responsible for central sensitization genesis, especially phenotypic changes in plasticity of neurons involved in the process are described. CONCLUSION: Pain chronicity may result from changes in central nervous system neurons properties by the central sensitization phenomenon with constant changes in membrane excitability, inhibitory transmission reduction and increase in synaptic efficacy mediated by several convergent and divergent molecular mechanisms over a background of phenotypic and structural changes. Neuroplasticity deeply alters painful sensation, contributing for many clinical painful syndromes and may represent a major target for therapeutic intervention.
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