精氨酸脱氨酶
精氨酸
瓜氨酸
酶
生物化学
精氨琥珀酸合成酶
化学
营养不良
支原体
氨基酸
生物
微生物学
大肠杆菌
基因
作者
Rakesh R. Somani,Pratip K. Chaskar
出处
期刊:Mini-reviews in Medicinal Chemistry
[Bentham Science]
日期:2018-01-22
卷期号:18 (4)
被引量:6
标识
DOI:10.2174/1389557516666160817102701
摘要
Some melanomas and hepatocellular carcinomas have been shown to be auxotrophic for arginine. Arginine deiminase (ADI), an arginine degrading enzyme isolated from Mycoplasma, can inhibit the growth of these tumors. It is a catabolizing enzyme which catabolizes arginine to Citrulline. Tumor cells do not express an enzyme called arginosuccinate synthetase (ASS) and hence, these cells become auxotrophic for arginine. It is found that ADI is specific for arginine and did not degrade other amino acid. This review covers various aspects of ADIs like origin, properties and chemical modifications for better antitumor activity. Keywords: Arginine, Arginine deiminase (ADI), Arginosuccinate synthetase (ASS), Arginosuccinate lyase (ASL), Hepatocellular carcinoma, malignant melanoma.
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