心功能曲线
功能(生物学)
人口
心脏发育
表型
神经科学
医学
生物
心力衰竭
心脏病学
细胞生物学
基因
遗传学
环境卫生
胚胎干细胞
作者
Demeng Qin,Ying Zhang,Fang Liu,Xiang Xu,Haiqiang Jiang,Zhaoliang Su,Lin Xia
摘要
Abstract Cardiac resident macrophages (CRMs) are integral components of the heart and play significant roles in cardiac development, steady‐state, and injury. Advances in sequencing technology have revealed that CRMs are a highly heterogeneous population, with significant differences in phenotype and function at different developmental stages and locations within the heart. In addition to research focused on diseases, recent years have witnessed a heightened interest in elucidating the involvement of CRMs in heart development and the maintenance of cardiac function. In this review, we primarily concentrated on summarizing the developmental trajectories, both spatial and temporal, of CRMs and their impact on cardiac development and steady‐state. Moreover, we discuss the possible factors by which the cardiac microenvironment regulates macrophages from the perspectives of migration, proliferation, and differentiation under physiological conditions. Gaining insight into the spatiotemporal heterogeneity and regulatory mechanisms of CRMs is of paramount importance in comprehending the involvement of macrophages in cardiac development, injury, and repair, and also provides new ideas and therapeutic methods for treating heart diseases.
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