狼疮性肾炎
足细胞
系统性红斑狼疮
肾炎
免疫学
医学
病理
肾
内科学
蛋白尿
疾病
标识
DOI:10.1016/j.clim.2024.110180
摘要
Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus, with high mortality rates despite medical advancements. The complexity of its pathogenesis, including the pivotal role of podocytes — kidney-localized cells — remains a challenge, lacking effective treatments and biomarkers. Recent studies highlight the significant contribution of these cells to LN's development, particularly through their immune-related functions and interaction with other kidney cells. This new understanding opens possibilities for targeted therapies aimed at these cellular mechanisms. This review aims to summarize these recent developments, shedding light on the intricate involvement of podocytes in LN and potential avenues for innovative treatments.
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