An NIR-driven biosensor based on the metal-enhanced fluorescence effect and a signal amplification strategy for miRNA detection

Herein, a fluorescent biosensor was used for the detection of miRNA-155 based on the UCNP@PDA/AuNP (UP/Au) composite and two TMSD steps. The proposed biosensor exhibited sensitive detection of miRNA-155 with a low limit of detection of 19.76 fM.