纳米传感器
细胞内
过氧化氢
化学
活性氧
电化学
生物物理学
癌细胞
纳米技术
核化学
组合化学
生物化学
癌症
材料科学
生物
电极
遗传学
物理化学
作者
Shuai Zhang,Hancheng Qin,Shuwen Cheng,Yue Zhang,Nan Gao,Meining Zhang
标识
DOI:10.1002/anie.202300083
摘要
Reactive oxygen species (ROS)-based therapeutic strategies play an important role in cancer treatment. However, in situ, real-time and quantitative analysis of intracellular ROS in cancer treatment for drug screening is still a challenge. Herein we report one selective hydrogen peroxide (H2 O2 ) electrochemical nanosensor, which is prepared by electrodeposition of Prussian blue (PB) and polyethylenedioxythiophene (PEDOT) onto carbon fiber nanoelectrode. With the nanosensor, we find that the level of intracellular H2 O2 increases with NADH treatment and that increase is dose-dependent to the concentration of NADH. High-dose of NADH (above 10 mM) can induce cell death and intratumoral injection of NADH is validated for inhibiting tumor growth in mice. This study highlights the potential of electrochemical nanosensor for tracking and understanding the role of H2 O2 in screening new anticancer drug.
科研通智能强力驱动
Strongly Powered by AbleSci AI