势垒函数
高海拔对人类的影响
机制(生物学)
肠道通透性
肠粘膜
肠上皮
生物
细胞生物学
医学
免疫学
上皮
内科学
哲学
遗传学
认识论
解剖
作者
Junfei Cheng,Yuemei Sun,Yilan Zhao,Qianwen Guo,Zihan Wang,Rong Wang
出处
期刊:Current Drug Delivery
[Bentham Science]
日期:2023-03-09
卷期号:20
标识
DOI:10.2174/1567201820666230309090241
摘要
The plateau is a typical extreme environment with low temperature, low oxygen and high ultraviolet rays. The integrity of the intestinal barrier is the basis for the functioning of the intestine, which plays an important role in absorbing nutrients, maintaining the balance of intestinal flora, and blocking the invasion of toxins. Currently, there is increasing evidence that high altitude environments can enhance intestinal permeability and disrupt intestinal barrier integrity. This article mainly focuses on the regulation of the expression of HIF and tight junction proteins in the high altitude environment, which promotes the release of pro-inflammatory factors, especially the imbalance of intestinal flora caused by the high altitude environment. The mechanism of intestinal barrier damage and the drugs to protect the intestinal barrier are reviewed. Studying the mechanism of intestinal barrier damage in high altitude environment is not only conducive to understanding the mechanism of high altitude environment affecting intestinal barrier function, but also provides a more scientific medicine treatment method for intestinal damage caused by the special high altitude environment.
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