低温保存
单层
金属有机骨架
化学工程
化学
材料科学
金属
氢
纳米技术
细胞生物学
有机化学
冶金
生物
工程类
吸附
胚胎
作者
Qi Lei,Yaqian Sun,Junda Huang,Wei Liu,Xiaolong Zhan,Wenxiang Yin,Sishi Guo,Anna Sinelshchikova,C. Jeffrey Brinker,Zhiyuan He,Jimin Guo,Stefan Wuttke,Wei Zhu
标识
DOI:10.1002/ange.202217374
摘要
To increase the red blood cell (RBC) cryopreservation efficiency by metal−organic frameworks (MOFs), a dimensional reduction approach has been proposed. Namely 3D MOF nanoparticles are progressively reduced to 2D ultra-thin metal–organic layers (MOLs). We found that 2D MOLs are beneficial for enhanced interactions of interfacial hydrogen-bonded water network and increased utilization of inner ordered structures, due to the higher surface-to-volume ratio. Specifically, a series of hafnium (Hf)-based 2D MOLs with different thickness (monolayer to stacked multilayers) and density of hydrogen bonding sites have been synthesized. Both ice recrystallization inhibition activity (IRI) and RBCs cryopreservation assay confirm the pronounced better IRI activity and excellent cell recovery efficiency (up to ~63% at a very low concentration of 0.7 mg mL–1) of thin-layered Hf-MOLs compared to their 3D counterparts, thereby verifying the dimensional reduction strategy to improved cryoprotectant behaviors.
科研通智能强力驱动
Strongly Powered by AbleSci AI