卵母细胞
男科
活性氧
线粒体
生物
线粒体DNA
细胞生物学
胚胎
医学
遗传学
基因
作者
Jiadan Qu,Lifeng Qin,Jing Guo,Zhu Ling,Yunjing Luo,Chong Li,Juan Xie,Jiaqiang Wang,Chunmeng Shi,Guoning Huang,Jingyu Li
标识
DOI:10.1016/j.biopha.2023.114571
摘要
Maternal aging is associated with a decline in oocyte quality, which leads to the decreased fertility. Therefore, developing approaches to reduce aging-induced deterioration of oocyte quality in older women is important. Near-infrared cell protector-61 (IR-61), a novel heptamethine cyanine dye, has the potential for antioxidant effects. In this study, we found that IR-61 can accumulate in the ovaries and improved ovarian function of naturally aged mice; it also increased the oocyte maturation rate and quality by maintaining the integrity of the spindle/chromosomal structure and reducing the aneuploidy rate. In addition, the embryonic developmental competence of aged oocytes was improved. Finally, RNA-sequencing analysis indicated that IR-61 might perform the beneficial effects on aged oocytes by regulating mitochondrial function, this was confirmed by immunofluorescence analysis of mitochondrial distribution and reactive oxygen species. Taken together, our findings demonstrate that IR-61 supplementation in vivo can increase oocyte quality and protect oocytes from aging-induced mitochondrial dysfunction, and thus could improve the fertility of older women and efficiency of assisted reproductive technology.
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