亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

EASIX-1year and late mortality after allogeneic stem cell transplantation

移植 干细胞 医学 生物 免疫学 内科学 细胞生物学
作者
Lambros Kordelas,Tobias Terzer,Ted Gooley,Chris Davis,Brenda M. Sandmaier,Mohamed L. Sorror,Olaf Penack,Nigel Dross Engelbert Schaeper,Igor Wolfgang Blau,Dietrich W. Beelen,Aleksandar Radujkovic,Peter Dreger,Thomas Luft
出处
期刊:Blood Advances [Elsevier BV]
卷期号:7 (18): 5374-5381 被引量:4
标识
DOI:10.1182/bloodadvances.2022008617
摘要

Abstract Patients with hematological malignancies who survive the first year after allogeneic stem cell transplantation (allo-SCT) without relapse have a substantial risk of nonrelapse mortality (NRM) and missing predictive markers. The Endothelial Activation and Stress Index (EASIX) predicts endothelial complications and NRM early after allo-SCT. We hypothesized that EASIX assessed 1 year after allo-SCT in survivors who were disease free may predict late NRM. Survivors who were relapse-free at 1 year after allo-SCT were retrospectively studied in 2 independent cohorts (training cohort, n = 610; merged validation cohort, n = 852). EASIX determined 1 year after allo-SCT correlated with the overall survival (OS), NRM, and relapse. Serum endothelial and inflammatory markers were measured in the training cohort and correlated with EASIX-1year, which predicted OS and NRM but not relapse risk in both the training and validation cohorts in univariable and multivariable Cox regression analyses. Brier score and c-index analyses validated the univariable EASIX effects. There was no significant interaction between EASIX-1year and incidence of chronic graft-versus-host disease (GVHD) on OS. EASIX-1year predicted the outcome irrespective of preexisting comorbidities. Principal causes of NRM in both training and validation cohorts were infections with and without GVHD as well as cardiovascular complications. EASIX-1year correlated with sCD141 and interleukin-18 but not with C-reactive protein, suppressor of tumorigenicity-2, angiopoietin-2, CXCL9, or CXCL8. To our knowledge, EASIX-1year is the first validated predictor of late overall and NRM. Patients who are high risk as defined by EASIX-1year might be considered for intensified surveillance and prophylactic measures.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
所所应助正直幼菱采纳,获得10
3秒前
Tania完成签到,获得积分10
9秒前
正直幼菱完成签到,获得积分10
28秒前
余晖霞光完成签到 ,获得积分10
37秒前
善学以致用应助火之高兴采纳,获得10
47秒前
edisonyan完成签到 ,获得积分10
1分钟前
punch完成签到 ,获得积分10
1分钟前
铖訾发布了新的文献求助10
1分钟前
伶俐的金连完成签到 ,获得积分10
1分钟前
铖訾完成签到,获得积分10
1分钟前
Smile完成签到,获得积分10
1分钟前
星辰大海应助科研通管家采纳,获得10
1分钟前
ppppppp_76完成签到 ,获得积分10
1分钟前
哈哈环完成签到 ,获得积分10
1分钟前
传奇3应助火星上的迎天采纳,获得10
2分钟前
2分钟前
2分钟前
有人应助HiNDT采纳,获得10
2分钟前
2分钟前
Smile发布了新的文献求助10
3分钟前
不能随便完成签到,获得积分10
3分钟前
JamesPei应助小笼包采纳,获得10
3分钟前
斯文败类应助科研通管家采纳,获得10
3分钟前
桐桐应助科研通管家采纳,获得10
3分钟前
3分钟前
激动的似狮完成签到,获得积分10
3分钟前
小笼包发布了新的文献求助10
3分钟前
科研通AI2S应助草木采纳,获得10
3分钟前
gszy1975完成签到,获得积分10
4分钟前
科研通AI2S应助Wei采纳,获得10
4分钟前
Ava应助曲幻梅采纳,获得10
4分钟前
4分钟前
曲幻梅发布了新的文献求助10
4分钟前
4分钟前
火之高兴发布了新的文献求助10
4分钟前
zyp应助草木采纳,获得10
4分钟前
火之高兴完成签到 ,获得积分20
5分钟前
Owen应助帕热达采纳,获得10
6分钟前
6分钟前
帕热达发布了新的文献求助10
6分钟前
高分求助中
【此为提示信息,请勿应助】请按要求发布求助,避免被关 20000
Encyclopedia of Geology (2nd Edition) 1000
CRC Handbook of Chemistry and Physics 104th edition 1000
Izeltabart tapatansine - AdisInsight 600
Introduction to Comparative Public Administration Administrative Systems and Reforms in Europe, Third Edition 3rd edition 500
Distinct Aggregation Behaviors and Rheological Responses of Two Terminally Functionalized Polyisoprenes with Different Quadruple Hydrogen Bonding Motifs 450
China—Art—Modernity: A Critical Introduction to Chinese Visual Expression from the Beginning of the Twentieth Century to the Present Day 360
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 物理 生物化学 纳米技术 计算机科学 化学工程 内科学 复合材料 物理化学 电极 遗传学 量子力学 基因 冶金 催化作用
热门帖子
关注 科研通微信公众号,转发送积分 3763564
求助须知:如何正确求助?哪些是违规求助? 3308109
关于积分的说明 10142712
捐赠科研通 3023204
什么是DOI,文献DOI怎么找? 1659454
邀请新用户注册赠送积分活动 792698
科研通“疑难数据库(出版商)”最低求助积分说明 755092