生物粘附
凝聚
化学
透明质酸
胶粘剂
抗菌活性
药物输送
生物化学
细菌
生物
有机化学
解剖
遗传学
图层(电子)
作者
Yang Zhao,Jia Kang,Yuting Cui,JI Sheng-li,Rui Nian,Wenfa Yu,Yue Sun
标识
DOI:10.1016/j.ijbiomac.2023.125773
摘要
In this work a bioadhesive was developed based on coacervates composed of recombinant mussel adhesive protein (MAP) and dopamine grafted hyaluronic acid (HA). Dopamine profoundly affected rheological attributes of the coacervates, leading to reduced rigidity, enhanced chain flexibility, more sol-like and fluid character and higher tolerance against structural collapse. The coacervates were rendered flowability, injectability, and adaptability, benefiting convenient delivery and making good contact with the skin to provide firm sealing for wounds of various shape and depth. It is the first time reported that MAP/HA coacervates are inherently antibacterial with 100 % growth inhibition against Gram-positive bacteria Staphylococcus aureus and Gram-negative bacteria Escherichia coli. The antibacterial capability was disclosed to be positively related to catechol content. To further enhance the coacervates bioactivity, a small bioactive peptide thymosin was added and was revealed to promote fibroblasts migration. The coacervates hold great potential as practical bioadhesives both from the perspective of rheological properties and biological activities.
科研通智能强力驱动
Strongly Powered by AbleSci AI