痴呆
医学
冲程(发动机)
认知
百分位
血压
睡眠剥夺对认知功能的影响
生命银行
认知功能衰退
家族史
内科学
老年学
人口学
精神科
生物信息学
生物
疾病
数学
工程类
社会学
统计
机械工程
作者
Cyprien Rivier,Natalia Szejko,Daniela Renedo,Rommell B. Noche,J. Acosta,Cameron Both,Richa Sharma,Victor Torres‐Lopez,Seyedmehdi Payabvash,Adam de Havenon,Kevin N. Sheth,Thomas M. Gill,Guido J. Falcone
出处
期刊:Neurology
[Lippincott Williams & Wilkins]
日期:2023-06-09
卷期号:101 (5)
被引量:2
标识
DOI:10.1212/wnl.0000000000207427
摘要
Mounting evidence indicates that hypertension leads to a higher risk of dementia. Hypertension is a highly heritable trait, and a higher polygenic susceptibility to hypertension (PSH) is known to associate with a higher risk of dementia. We tested the hypothesis that a higher PSH leads to worse cognitive performance in middle-aged persons without dementia. Confirming this hypothesis would support follow-up research focused on using hypertension-related genomic information to risk-stratify middle-aged adults before hypertension develops.
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