PI3K/AKT/mTOR通路
莫里斯水上航行任务
蛋白激酶B
药理学
氧化应激
医学
化学
炎症
细胞凋亡
内科学
海马体
生物化学
作者
Yinhuang Gao,Peng Zhao,Chunyan Wang,Keren Fang,Yueqing Pan,Yan Zhang,Zhishuo Miao,Meirong Wang,Minlong Wei,Wei Zou,Menghua Liu,Kang Peng
出处
期刊:Phytomedicine
[Elsevier]
日期:2024-06-25
卷期号:132: 155844-155844
标识
DOI:10.1016/j.phymed.2024.155844
摘要
Chronic cerebral hypoperfusion (CCH) has been confirmed as one of the pathogenesis underlying vascular cognitive impairment. A series of pathological changes, including inflammation, oxidative stress, and apoptosis, are involved in this pathophysiology and contribute to cognitive impairment and neuropathological alterations. The traditional Chinese medicine (TCM) of Buqi Huoxue Tongnao (BQHXTN) prescription possesses a remarkable clinical efficacy for treating patients with CCH, but still lacks a scientific foundation for its pharmacological mechanisms.
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