Diagnostic Performance of Noninvasive Tests for Advanced Hepatic Fibrosis in Young Age Population

医学 非酒精性脂肪肝 内科学 胃肠病学 磁共振弹性成像 队列 病因学 肝纤维化 接收机工作特性 肝硬化 纤维化 脂肪肝 肝病 慢性肝病 磁共振成像 代谢综合征 瞬态弹性成像 疾病 弹性成像 肝纤维化 肥胖 放射科 超声波
作者
Mimi Kim,Eileen L. Yoon,Jonghyun Lee,Seon Cho,Chul‐min Lee,Bo-Kyeong Kang,Huiyul Park,Dae Won Jun,Eun‐Hee Nah
出处
期刊:Clinical Gastroenterology and Hepatology [Elsevier BV]
卷期号:21 (7): 1831-1840.e12 被引量:2
标识
DOI:10.1016/j.cgh.2022.10.020
摘要

Background & Aims Most noninvasive tests (NITs) for hepatic fibrosis are designed for middle-aged patients with chronic liver disease. We compared the diagnostic performance of major NITs (aspartate aminotransferase–to-platelet ratio index [APRI], Fibrosis-4 index, and nonalcoholic fatty liver disease fibrosis score) for a community-based cohort. Methods This cross-sectional study analyzed 8775 participants who underwent magnetic resonance elastography at community health check-up centers. Advanced hepatic fibrosis (≥F3) was defined by magnetic resonance elastography thresholds of 3.6 kPa. The diagnostic performance of 3 NITs was evaluated according to the etiology of liver disease, sex, metabolic syndrome, obesity, and increased aminotransferase levels in 4 age groups. Results The APRI generally showed the best area under the receiver operating characteristic curve in patients aged 45 years or younger, and it was statistically significant in patients with chronic viral hepatitis and alcoholic fatty liver disease (P < .043). The best APRI cut-off value for detecting advanced hepatic fibrosis was 0.4, with a sensitivity and specificity of 75.8% and 73.5%, respectively, in the community-based cohort. The APRI showed balanced sensitivity and specificity across all age groups, whereas the other metrics showed low sensitivity in those aged <45 and low specificity in those >65 years. Conclusions The APRI showed better sensitivity and negative predictive value than the Fibrosis-4 index and the nonalcoholic fatty liver disease fibrosis score in community-based populations with mixed etiology, and, thus, can be performed as the primary test in young adults (age, ≤45 y). Most noninvasive tests (NITs) for hepatic fibrosis are designed for middle-aged patients with chronic liver disease. We compared the diagnostic performance of major NITs (aspartate aminotransferase–to-platelet ratio index [APRI], Fibrosis-4 index, and nonalcoholic fatty liver disease fibrosis score) for a community-based cohort. This cross-sectional study analyzed 8775 participants who underwent magnetic resonance elastography at community health check-up centers. Advanced hepatic fibrosis (≥F3) was defined by magnetic resonance elastography thresholds of 3.6 kPa. The diagnostic performance of 3 NITs was evaluated according to the etiology of liver disease, sex, metabolic syndrome, obesity, and increased aminotransferase levels in 4 age groups. The APRI generally showed the best area under the receiver operating characteristic curve in patients aged 45 years or younger, and it was statistically significant in patients with chronic viral hepatitis and alcoholic fatty liver disease (P < .043). The best APRI cut-off value for detecting advanced hepatic fibrosis was 0.4, with a sensitivity and specificity of 75.8% and 73.5%, respectively, in the community-based cohort. The APRI showed balanced sensitivity and specificity across all age groups, whereas the other metrics showed low sensitivity in those aged <45 and low specificity in those >65 years. The APRI showed better sensitivity and negative predictive value than the Fibrosis-4 index and the nonalcoholic fatty liver disease fibrosis score in community-based populations with mixed etiology, and, thus, can be performed as the primary test in young adults (age, ≤45 y).
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
魁梧的盼望完成签到 ,获得积分10
刚刚
量子星尘发布了新的文献求助30
1秒前
4秒前
wzk完成签到,获得积分10
5秒前
称心翠容完成签到,获得积分10
7秒前
LaixS完成签到,获得积分10
8秒前
尊敬代亦发布了新的文献求助10
9秒前
要笑cc完成签到,获得积分10
10秒前
青珊发布了新的文献求助10
12秒前
宣宣宣0733完成签到,获得积分10
12秒前
俊逸吐司完成签到 ,获得积分10
13秒前
ttxxcdx完成签到 ,获得积分10
14秒前
胡质斌完成签到,获得积分10
14秒前
充电宝应助科研通管家采纳,获得10
17秒前
18秒前
姚怜南完成签到,获得积分10
20秒前
青珊完成签到,获得积分10
22秒前
自觉石头完成签到 ,获得积分10
23秒前
VVTTWW完成签到 ,获得积分10
25秒前
感性的寄真完成签到 ,获得积分10
27秒前
zhang完成签到,获得积分10
30秒前
33秒前
比比谁的速度快应助zhang采纳,获得50
37秒前
绿袖子完成签到,获得积分10
39秒前
46秒前
刘刘完成签到 ,获得积分10
47秒前
执着夏岚完成签到 ,获得积分10
47秒前
Xzx1995完成签到 ,获得积分10
51秒前
Hululu完成签到 ,获得积分10
53秒前
淡然的芷荷完成签到 ,获得积分10
54秒前
GT完成签到,获得积分10
56秒前
qiancib202完成签到,获得积分10
59秒前
量子星尘发布了新的文献求助10
1分钟前
等待的幼晴完成签到,获得积分10
1分钟前
负责灵萱完成签到 ,获得积分10
1分钟前
幽默的忆霜完成签到 ,获得积分10
1分钟前
1分钟前
1分钟前
风光无限完成签到 ,获得积分20
1分钟前
庄海棠完成签到 ,获得积分10
1分钟前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038029
求助须知:如何正确求助?哪些是违规求助? 3575740
关于积分的说明 11373751
捐赠科研通 3305559
什么是DOI,文献DOI怎么找? 1819224
邀请新用户注册赠送积分活动 892652
科研通“疑难数据库(出版商)”最低求助积分说明 815022