医学
疾病
生物信息学
人口
炎症
离子通道
神经科学
免疫学
生物
内科学
受体
环境卫生
作者
Renpeng Zhou,Yukui Zhang,Weirong Hu,Jie Ding,Shufang Li,Yong Chen,Yingjie Zhao,Chao Lü,Feihu Chen,Wei Hu
标识
DOI:10.1016/j.arr.2022.101785
摘要
Age-related diseases have become more common with the advancing age of the worldwide population. Such diseases involve multiple organs, with tissue degeneration and cellular apoptosis. To date, there is a general lack of effective drugs for treatment of most age-related diseases and there is therefore an urgent need to identify novel drug targets for improved treatment. Acid-sensing ion channel 1a (ASIC1a) is a degenerin/epithelial sodium channel family member, which is activated in an acidic environment to regulate pathophysiological processes such as acidosis, inflammation, hypoxia, and ischemia. A large body of evidence suggests that ASIC1a plays an important role in the development of age-related diseases (e.g., stroke, rheumatoid arthritis, Huntington's disease, and Parkinson's disease.). Herein we present: 1) a review of ASIC1a channel properties, distribution, and physiological function; 2) a summary of the pharmacological properties of ASIC1a; 3) and a consideration of ASIC1a as a potential therapeutic target for treatment of age-related disease.
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