免疫原性
免疫系统
肿瘤进展
微生物学
医学
生物
免疫学
癌症研究
癌症
内科学
作者
Jingjing Zhang,Shuangshuang Wan,Hao Zhou,Jiaxin Du,Yaocheng Li,Houjuan Zhu,Lixing Weng,Xianguang Ding,Lianhui Wang
出处
期刊:ACS Nano
[American Chemical Society]
日期:2024-03-19
卷期号:18 (13): 9613-9626
被引量:7
标识
DOI:10.1021/acsnano.3c13194
摘要
Recent discoveries in commensal microbiota demonstrate the great promise of intratumoral bacteria as attractive molecular targets of tumors in improving cancer treatment. However, direct leveraging of in vivo antibacterial strategies such as antibiotics to potentiate cancer therapy often leads to uncertain effectiveness, mainly due to poor selectivity and potential adverse effects. Here, building from the clinical discovery that patients with breast cancer featured rich commensal bacteria, we developed an activatable biointerface by encapsulating commensal bacteria-derived extracellular vesicles (BEV) with a responsive nanocloak to potentiate immunoreactivity against intratumoral bacteria and breast cancer. We show that the interfacially cloaked BEV (cBEV) not only overcame serious systemic side responses but also demonstrated heightened immunogenicity by intercellular responsive immunogenicity, facilitating dendritic cell maturation through activating the cGAS-STING pathway. As a preventive measure, vaccination with nanocloaked cBEVs achieved strong protection against bacterial infection, largely providing prophylactic efficiency against tumor challenges. When treated in conjunction with immune checkpoint inhibitor anti-PD-L1 antibodies, the combined approach elicited a potent tumor-specific immune response, synergistically inhibiting tumor progression and mitigating lung metastases.
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