Research progress in construction of organic carrier drug delivery platform using tumor microenvironment

At present, chemotherapy is still the main method for treatment of cancer, which can effectively kill cancer cells and control the metastasis of cancer cells. However, traditional chemotherapy methods not only produce many painful adverse reactions to the patient 's body, but also are limited by the shortcomings of tumor multidrug resistance, drug non-specificity and toxic side effects on the body. Nano drug delivery system is the main research direction of chemotherapy in recent five years. By designing a series of tumor microenvironment stimuli-responsive nano carrier systems, the effect of targeted drug release according to the changes of tumor microenvironment or external environment can be achieved, so as to increase the absorption of drugs in tumor cells, improve the biological distribution and aggregation of tumor sites, and make targeted drug therapy possible. Nanocarriers exhibit different properties to tumor microenvironment under different treatment methods. In this paper, the advantages and disadvantages of different types of drug carrier systems were compared by analyzing the administration efficiency and influencing factors of different types of drug carrier systems (including polymer micelles, liposomes, nanospheres, hydrogels, microcapsules, cyclodextrins, and biopeptides). By summarizing the design of high-performance nano-tumor drug carriers, the difficulties faced in the field of nano-drug delivery are proposed, which provides new ideas for new chemotherapy methods.