Early detection of pancreatic cancer and AI risk partitioning

Pancreatic cancer is on the rise globally, and usually presents at advanced metastatic stages, inoperable, with little responsiveness to chemotherapy. Early diagnosis has been associated with better outcomes, but only a minority of pancreatic cancer cases are diagnosed at a stage when the tumour is surgically operable. Current guidance for pancreatic cancer surveillance is restricted to high-risk individuals (HRIs) who have germline mutations that predispose to a lifetime increased risk of pancreatic cancer or a strong family history of pancreatic cancer.