Nitrate ingestion blunts the increase in blood pressure during cool air exposure. A double-blind, placebo-controlled, randomized, crossover trial

亚硝酸盐 交叉研究 硝酸盐 一氧化氮 摄入 动物科学 血压 化学 安慰剂 生物利用度 内科学 医学 生物化学 药理学 生物 替代医学 有机化学 病理
作者
Samantha N. Rowland,Emma O’Donnell,Lewis J. James,Mariasole Da Boit,Naoto Fujii,Josh T. Arnold,Alex Lloyd,Clare Eglin,Anthony I. Shepherd,Stephen J. Bailey
出处
期刊:Journal of Applied Physiology [American Physiological Society]
卷期号:136 (6): 1364-1375
标识
DOI:10.1152/japplphysiol.00593.2023
摘要

Cold exposure increases blood pressure (BP) and salivary flow rate (SFR). Increased cold-induced SFR would be hypothesized to enhance oral nitrate delivery for reduction to nitrite by oral anaerobes and to subsequently elevate plasma [nitrite] and nitric oxide bioavailability. We tested the hypothesis that dietary nitrate supplementation would increase plasma [nitrite] and lower BP to a greater extent in cool compared with normothermic conditions. Twelve males attended the laboratory on four occasions. Baseline measurements were completed at 28°C. Subsequently, participants ingested 140 mL of concentrated nitrate-rich (BR; ∼13 mmol nitrate) or nitrate-depleted (PL) beetroot juice. Measurements were repeated over 3 h at either 28°C (Norm) or 20°C (Cool). Mean skin temperature was lowered compared with baseline in PL-Cool and BR-Cool. SFR was greater in BR-Norm, PL-Cool, and BR-Cool than PL-Norm. Plasma [nitrite] at 3 h was higher in BR-Cool (592 ± 239 nM) versus BR-Norm (410 ± 195 nM). Systolic BP (SBP) at 3 h was not different between PL-Norm (117 ± 6 mmHg) and BR-Norm (113 ± 9 mmHg). SBP increased above baseline at 1, 2, and 3 h in PL-Cool but not BR-Cool. These results suggest that BR consumption is more effective at increasing plasma [nitrite] in cool compared with normothermic conditions and blunts the rise in BP following acute cool air exposure, which might have implications for attenuating the increased cardiovascular strain in the cold.

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