Variation of NT-proBNP and High-Sensitivity Cardiac Troponin T Across Levels of Estimated Glomerular Filtration Rate: The SPRINT Trial

HomeCirculationVol. 149, No. 12Variation of NT-proBNP and High-Sensitivity Cardiac Troponin T Across Levels of Estimated Glomerular Filtration Rate: The SPRINT Trial No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextVariation of NT-proBNP and High-Sensitivity Cardiac Troponin T Across Levels of Estimated Glomerular Filtration Rate: The SPRINT Trial Nisha Bansal, Ronit Katz, Stephen Seliger, Christopher deFilippi, Nicholas Wettersten, James A. de Lemos, Robert Christenson, Anthony A. Killeen, Jarett D. Berry, Michael G. Shlipak and Joachim H. Ix Nisha BansalNisha Bansal Correspondence to: Nisha Bansal, MD, Division of Nephrology, University of Washington, 908 Jefferson St, 3rd Floor, Seattle, WA 98104. Email E-mail Address: [email protected] https://orcid.org/0000-0002-9583-8628 Division of Nephrology (N.B.), University of Washington, Seattle. , Ronit KatzRonit Katz https://orcid.org/0000-0001-7723-7469 Department of Obstetrics and Gynecology (R.K.), University of Washington, Seattle. , Stephen SeligerStephen Seliger https://orcid.org/0000-0002-1693-0734 Division of Nephrology, University of Maryland School of Medicine, Baltimore (S.S.). , Christopher deFilippiChristopher deFilippi https://orcid.org/0000-0002-0660-4943 Inova Health System, Falls Church, VA (C.F.). , Nicholas WetterstenNicholas Wettersten https://orcid.org/0000-0002-6122-1152 Division of Cardiology, VA San Diego Healthcare System, CA (N.W.). , James A. de LemosJames A. de Lemos https://orcid.org/0000-0003-2211-7261 Division of Cardiology, University of Texas Southwestern, Dallas (J.A.L., J.D.B.). , Robert ChristensonRobert Christenson https://orcid.org/0000-0003-2612-9083 Department of Pathology, University of Maryland, Baltimore (R.C.). , Anthony A. KilleenAnthony A. Killeen https://orcid.org/0000-0003-1629-9468 Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis (A.A.K.). , Jarett D. BerryJarett D. Berry https://orcid.org/0000-0002-5004-8155 Division of Cardiology, University of Texas Southwestern, Dallas (J.A.L., J.D.B.). , Michael G. ShlipakMichael G. Shlipak https://orcid.org/0000-0002-9559-204X Department of Medicine, University of California San Francisco, and San Francisco Veterans Affairs Hospital (M.G.S.). and Joachim H. IxJoachim H. Ix Division of Nephrology, University of California San Diego, and Veterans Affairs San Diego Healthcare System (J.H.I.). Originally published18 Mar 2024https://doi.org/10.1161/CIRCULATIONAHA.123.066377Circulation. 2024;149:967–969Footnotes*M.G. Shlipak and J.H. Ix contributed equally.This manuscript was sent to Allan Jaffe, Guest Editor, for review by expert referees, editorial decision, and final disposition.For Sources of Funding and Disclosures, see page 969.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Nisha Bansal, MD, Division of Nephrology, University of Washington, 908 Jefferson St, 3rd Floor, Seattle, WA 98104. Email nbansal@nephrology.washington.eduREFERENCES1. Bansal N, Zelnick LR, Ballantyne CM, Chaves PHM, Christenson RH, Coresh J, deFilippi CR, de Lemos JA, Daniels LB, Go AS, et al; CRIC Study Investigators. Upper reference limits for high-sensitivity cardiac troponin T and N-terminal fragment of the prohormone brain natriuretic peptide in patients with CKD.Am J Kidney Dis. 2022; 79:383–392. doi: 10.1053/j.ajkd.2021.06.017CrossrefMedlineGoogle Scholar2. Wright JT, Williamson JD, Whelton PK, Snyder JK, Sink KM, Rocco MV, Reboussin DM, Rahman M, Oparil S, Lewis CE, et al; SPRINT Research Group. A randomized trial of intensive versus standard blood-pressure control.N Engl J Med. 2015; 373:2103–2116. doi: 10.1056/NEJMoa1511939CrossrefMedlineGoogle Scholar3. Berry JD, Nambi V, Ambrosius WT, Chen H, Killeen AA, Taylor A, Toto RD, Soliman EZ, McEvoy JW, Pandey A, et al. Associations of high-sensitivity troponin and natriuretic peptide levels with outcomes after intensive blood pressure lowering: findings from the SPRINT randomized clinical trial.JAMA Cardiol. 2021; 6:1397–1405. doi: 10.1001/jamacardio.2021.3187CrossrefMedlineGoogle Scholar4. O'Hanlon R, O'Shea P, Ledwidge M, O'Loughlin C, Lange S, Conlon C, Phelan D, Cunningham S, McDonald K. The biologic variability of B-type natriuretic peptide and N-terminal pro-B-type natriuretic peptide in stable heart failure patients.J Card Fail. 2007; 13:50–55. doi: 10.1016/j.cardfail.2006.09.003CrossrefMedlineGoogle Scholar5. Vasile VC, Saenger AK, Kroning JM, Jaffe AS. Biological and analytical variability of a novel high-sensitivity cardiac troponin T assay.Clin Chem. 2010; 56:1086–1090. doi: 10.1373/clinchem.2009.140616CrossrefMedlineGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. 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